1,3-Dioxane-4-acetic acid, 6-[2-[2-(4-fluorophenyl)-4-[[[4-(hydroxymethyl)phenyl]amino]carbonyl]-5-( 1-methylethyl)-3-phenyl-1H-pyrrol-1-yl]ethyl]-2,2-dimethyl-, 1,1-dimethylethyl ester, (4R,6R)-

Base Information

Chemical Name:1,3-Dioxane-4-acetic acid, 6-[2-[2-(4-fluorophenyl)-4-[[[4-(hydroxymethyl)phenyl]amino]carbonyl]-5-( 1-methylethyl)-3-phenyl-1H-pyrrol-1-yl]ethyl]-2,2-dimethyl-, 1,1-dimethylethyl ester, (4R,6R)-
CAS No.:805241-63-8
Molecular Formula:C41H49FN2O6
Molecular Weight:684.848
Hs Code.:

1,3-Dioxane-4-acetic acid,
6-[2-[2-(4-fluorophenyl)-4-[[[4-(hydroxymethyl)phenyl]amino]carbonyl]-5-(
1-methylethyl)-3-phenyl-1H-pyrrol-1-yl]ethyl]-2,2-dimethyl-,
1,1-dimethylethyl ester, (4R,6R)-

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Chemical Property of 1,3-Dioxane-4-acetic acid, 6-[2-[2-(4-fluorophenyl)-4-[[[4-(hydroxymethyl)phenyl]amino]carbonyl]-5-( 1-methylethyl)-3-phenyl-1H-pyrrol-1-yl]ethyl]-2,2-dimethyl-, 1,1-dimethylethyl ester, (4R,6R)-

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Technology Process of 1,3-Dioxane-4-acetic acid, 6-[2-[2-(4-fluorophenyl)-4-[[[4-(hydroxymethyl)phenyl]amino]carbonyl]-5-( 1-methylethyl)-3-phenyl-1H-pyrrol-1-yl]ethyl]-2,2-dimethyl-, 1,1-dimethylethyl ester, (4R,6R)-

There total 13 articles about 1,3-Dioxane-4-acetic acid, 6-[2-[2-(4-fluorophenyl)-4-[[[4-(hydroxymethyl)phenyl]amino]carbonyl]-5-( 1-methylethyl)-3-phenyl-1H-pyrrol-1-yl]ethyl]-2,2-dimethyl-, 1,1-dimethylethyl ester, (4R,6R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 4-(1-{2-[(4R,6R)-6-[2-(tert-butoxy)-2-oxoethyl]-2,2-dimethyl-1,3-dioxan-4-yl]ethyl}-5-(4-fluorophenyl)-4-phenyl-2-(propan-2-yl)-1H-pyrrole-3-amido)benzoic acid

: 805241-63-8
tert-butyl 2-[(4R,6R)-6-{2-[2-(4-fluorophenyl)-4-{[4-(hydroxymethyl)phenyl]carbamoyl}-3-phenyl-5-(propan-2-yl)-1H-pyrrol-1-yl]ethyl}-2,2-dimethyl-1,3-dioxan-4-yl]acetate

Guidance literature:: With dimethylsulfide borane complex; In tetrahydrofuran; at 0 - 45 ℃; for 24h; Large scale;

Reference yield: 70.0%

: 2-(2-(4-fluorophenyl)-2-oxo-1-phenylethyl)-N-(4-(hydroxymethyl)phenyl)-4-methyl-3-oxopentanamide

: 125971-86-0,125995-13-3
tert-butyl [(4R,6R)-6-aminoethyl-2,2-dimethyl-1,3-dioxan-4-yl]acetate

: 805241-63-8
tert-butyl 2-[(4R,6R)-6-{2-[2-(4-fluorophenyl)-4-{[4-(hydroxymethyl)phenyl]carbamoyl}-3-phenyl-5-(propan-2-yl)-1H-pyrrol-1-yl]ethyl}-2,2-dimethyl-1,3-dioxan-4-yl]acetate

Guidance literature:: With Trimethylacetic acid; In tetrahydrofuran; n-heptane; toluene; Dean-Stark;

Reference yield:

: 103-80-0
phenylacetyl chloride

: 805241-63-8
tert-butyl 2-[(4R,6R)-6-{2-[2-(4-fluorophenyl)-4-{[4-(hydroxymethyl)phenyl]carbamoyl}-3-phenyl-5-(propan-2-yl)-1H-pyrrol-1-yl]ethyl}-2,2-dimethyl-1,3-dioxan-4-yl]acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: aluminum (III) chloride / 1 h / 0 - 5 °C

2.1: hydrogen bromide; bromine / dichloromethane / 0 - 5 °C

3.1: potassium carbonate / acetone / 0.17 h

3.2: 12 h / 25 - 35 °C

4.1: trifluoroacetic acid / dichloromethane; methanol / 2 h / 30 - 35 °C

5.1: Trimethylacetic acid / toluene; tetrahydrofuran; n-heptane / Dean-Stark

With aluminum (III) chloride; hydrogen bromide; bromine; potassium carbonate; trifluoroacetic acid; Trimethylacetic acid; In tetrahydrofuran; methanol; n-heptane; dichloromethane; acetone; toluene;