tert-butyl 2-[(4R,6R)-6-{2-[2-(4-fluorophenyl)-4-{[4-(hydroxymethyl)phenyl]carbamoyl}-3-phenyl-5-(propan-2-yl)-1H-pyrrol-1-yl]ethyl}-2,2-dimethyl-1,3-dioxan-4-yl]acetate

Base Information

Chemical Name:tert-butyl 2-[(4R,6R)-6-{2-[2-(4-fluorophenyl)-4-{[4-(hydroxymethyl)phenyl]carbamoyl}-3-phenyl-5-(propan-2-yl)-1H-pyrrol-1-yl]ethyl}-2,2-dimethyl-1,3-dioxan-4-yl]acetate
CAS No.:936756-74-0
Molecular Formula:C₃₈H₄₅FN₂O₆
Molecular Weight:644.784
Hs Code.:

tert-butyl 2-[(4R,6R)-6-{2-[2-(4-fluorophenyl)-4-{[4-(hydroxymethyl)phenyl]carbamoyl}-3-phenyl-5-(propan-2-yl)-1H-pyrrol-1-yl]ethyl}-2,2-dimethyl-1,3-dioxan-4-yl]acetate

Synonyms:tert-butyl 2-[(4R,6R)-6-{2-[2-(4-fluorophenyl)-4-{[4-(hydroxymethyl)phenyl]carbamoyl}-3-phenyl-5-(propan-2-yl)-1H-pyrrol-1-yl]ethyl}-2,2-dimethyl-1,3-dioxan-4-yl]acetate

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Chemical Property of tert-butyl 2-[(4R,6R)-6-{2-[2-(4-fluorophenyl)-4-{[4-(hydroxymethyl)phenyl]carbamoyl}-3-phenyl-5-(propan-2-yl)-1H-pyrrol-1-yl]ethyl}-2,2-dimethyl-1,3-dioxan-4-yl]acetate

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Technology Process of tert-butyl 2-[(4R,6R)-6-{2-[2-(4-fluorophenyl)-4-{[4-(hydroxymethyl)phenyl]carbamoyl}-3-phenyl-5-(propan-2-yl)-1H-pyrrol-1-yl]ethyl}-2,2-dimethyl-1,3-dioxan-4-yl]acetate

There total 20 articles about tert-butyl 2-[(4R,6R)-6-{2-[2-(4-fluorophenyl)-4-{[4-(hydroxymethyl)phenyl]carbamoyl}-3-phenyl-5-(propan-2-yl)-1H-pyrrol-1-yl]ethyl}-2,2-dimethyl-1,3-dioxan-4-yl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 805241-63-8
tert-butyl 2-[(4R,6R)-6-{2-[2-(4-fluorophenyl)-4-{[4-(hydroxymethyl)phenyl]carbamoyl}-3-phenyl-5-(propan-2-yl)-1H-pyrrol-1-yl]ethyl}-2,2-dimethyl-1,3-dioxan-4-yl]acetate

: 936756-74-0
tert-butyl 2-[(4R,6R)-6-{2-[2-(4-fluorophenyl)-4-{[4-(hydroxymethyl)phenyl]carbamoyl}-3-phenyl-5-(propan-2-yl)-1H-pyrrol-1-yl]ethyl}-2,2-dimethyl-1,3-dioxan-4-yl]acetate

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; methanol; water; at 20 ℃; for 2h;

Reference yield: 66.56%

: 936756-73-9
[(4R,6R)-6-(2-{2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-[(4-(tetrahydropyran-2-yl-oxymethyl)phenylamino)carbonyl]pyrrol-1-yl}ethyl)-2,2-dimethyl-[1,3]-dioxan-4-yl]-acetic acid tert-butyl ester

: 936756-74-0
tert-butyl 2-[(4R,6R)-6-{2-[2-(4-fluorophenyl)-4-{[4-(hydroxymethyl)phenyl]carbamoyl}-3-phenyl-5-(propan-2-yl)-1H-pyrrol-1-yl]ethyl}-2,2-dimethyl-1,3-dioxan-4-yl]acetate

Guidance literature:: With hydrogenchloride; methanol; water; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 103-80-0
phenylacetyl chloride

: 936756-74-0
tert-butyl 2-[(4R,6R)-6-{2-[2-(4-fluorophenyl)-4-{[4-(hydroxymethyl)phenyl]carbamoyl}-3-phenyl-5-(propan-2-yl)-1H-pyrrol-1-yl]ethyl}-2,2-dimethyl-1,3-dioxan-4-yl]acetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: aluminum (III) chloride / 1 h / 0 - 5 °C

2.1: hydrogen bromide; bromine / dichloromethane / 0 - 5 °C

3.1: potassium carbonate / acetone / 0.17 h

3.2: 12 h / 25 - 35 °C

4.1: trifluoroacetic acid / dichloromethane; methanol / 2 h / 30 - 35 °C

5.1: Trimethylacetic acid / toluene; tetrahydrofuran; n-heptane / Dean-Stark

6.1: hydrogenchloride / methanol; tetrahydrofuran; water / 2 h / 20 °C

With hydrogenchloride; aluminum (III) chloride; hydrogen bromide; bromine; potassium carbonate; trifluoroacetic acid; Trimethylacetic acid; In tetrahydrofuran; methanol; n-heptane; dichloromethane; water; acetone; toluene;