2-Pyrrolidinone, 3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-[[[(1,1-dimethylethyl)dimethylsil yl]oxy]methyl]-1-[(1S)-1-phenylethyl]-, (3R,4R)-

Base Information

• Chemical Name: 2-Pyrrolidinone, 3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-[[[(1,1-dimethylethyl)dimethylsil yl]oxy]methyl]-1-[(1S)-1-phenylethyl]-, (3R,4R)-
• CAS No.: 807626-30-8
• Molecular Formula: C25H45NO3Si2
• Molecular Weight: 463.808

Synonyms:

Chemical Property of 2-Pyrrolidinone, 3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-[[[(1,1-dimethylethyl)dimethylsil yl]oxy]methyl]-1-[(1S)-1-phenylethyl]-, (3R,4R)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Pyrrolidinone, 3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-[[[(1,1-dimethylethyl)dimethylsil yl]oxy]methyl]-1-[(1S)-1-phenylethyl]-, (3R,4R)-

There total 7 articles about 2-Pyrrolidinone, 3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-[[[(1,1-dimethylethyl)dimethylsil yl]oxy]methyl]-1-[(1S)-1-phenylethyl]-, (3R,4R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

tert-butyldimethylsilyl chloride (18162-48-6) + (3R,4R,1'S)-3-tert-butyldimethylsilyloxy-4-hydroxymethyl-1-(1'-phenylethyl)pyrrolidin-2-one (807626-27-3) → (3R,4R,1'S)-3-tert-butyldimethylsilyloxy-4-tert-butyldimethylsilyloxymethyl-1-(1'-phenylethyl)pyrrolidin-2-one (807626-30-8)

Guidance literature:

With 1H-imidazole; In dichloromethane; at 20 ℃; for 5h;

DOI:10.1016/j.tetasy.2004.08.016

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) + (3R,4R)-3-Hydroxy-4-hydroxymethyl-1-((S)-1-phenyl-ethyl)-pyrrolidin-2-one (1050335-62-0) → (3R,4R,1'S)-3-tert-butyldimethylsilyloxy-4-tert-butyldimethylsilyloxymethyl-1-(1'-phenylethyl)pyrrolidin-2-one (807626-30-8)

Guidance literature:

With 1H-imidazole; In dichloromethane; at 20 ℃; for 6h;

DOI:10.1016/j.tetasy.2004.08.016

Reference yield:

1-Ethyl 4-methyl 2-hydroxy 3-methylenebutanedioate (108735-94-0) → (3R,4R,1'S)-3-tert-butyldimethylsilyloxy-4-tert-butyldimethylsilyloxymethyl-1-(1'-phenylethyl)pyrrolidin-2-one (807626-30-8)

Guidance literature:

Multi-step reaction with 3 steps

1: methanol / 20 h / 20 °C

2: LiAlH₄ / tetrahydrofuran / 0 - 20 °C

3: 1.37 g / imidazole / CH₂Cl₂ / 6 h / 20 °C

With 1H-imidazole; lithium aluminium tetrahydride; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1016/j.tetasy.2004.08.016

upstream raw materials:

tert-butyldimethylsilyl chloride

(3R,4R)-3-Hydroxy-4-hydroxymethyl-1-((S)-1-phenyl-ethyl)-pyrrolidin-2-one

(3R,4R,1'S)-3-tert-butyldimethylsilyloxy-4-hydroxymethyl-1-(1'-phenylethyl)pyrrolidin-2-one

1-Ethyl 4-methyl 2-hydroxy 3-methylenebutanedioate

Downstream raw materials:

(3R,4R,1'S)-3-acetoxy-4-acetoxymethyl-1-(1'-phenylethyl)pyrrolidine

(3R,4R)-3-hydroxy-4-(hydroxymethyl)pyrrolidine

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