Hexadecanoic acid 3-hydroxypropyl ester

Base Information

• Chemical Name: Hexadecanoic acid 3-hydroxypropyl ester
• CAS No.: 821-16-9
• Molecular Formula: C19H38O3
• Molecular Weight: 314.50300
• Mol file: 821-16-9.mol

Synonyms:Propandiol-(1,3)-monopalmitinsaeureester;Hexadecanoic acid,3-hydroxypropyl ester;palmitic acid-(3-hydroxy-propyl ester);P-1160;1-Palmitoyloxy-propanol-(3);Palmitinsaeure-(3-hydroxy-propylester);Mono-O-palmitoyl-propandiol-(1.3);

Chemical Property of Hexadecanoic acid 3-hydroxypropyl ester

Chemical Property:

• PSA: 46.53000
• LogP: 5.39330

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Hexadecanoic acid 3-hydroxypropyl ester

There total 5 articles about Hexadecanoic acid 3-hydroxypropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1-hexadecylcarboxylic acid (57-10-3) + propan-1-ol-3-amine (156-87-6) → 3-hydroxypropyl hexadecanoate (821-16-9)

Guidance literature:

With propane-1,3-diyl dinitrite; In tert-butyl alcohol; at 80 ℃; for 6h; Solvent;

DOI:10.1039/d0cc03242e

Reference yield: 86.0%

trimethyleneglycol (504-63-2) + n-hexadecanoyl chloride (112-67-4) → 3-hydroxypropyl hexadecanoate (821-16-9)

Guidance literature:

With pyridine; In dichloromethane; at 0 ℃;

DOI:10.1021/jm5020082

Reference yield:

potassium palmitate (2624-31-9) + 1-bromo-3-propanol (627-18-9) → 3-hydroxypropyl hexadecanoate (821-16-9)

Guidance literature:

at 120 ℃;

upstream raw materials:

trimethyleneglycol

n-hexadecanoyl chloride

potassium palmitate

1-bromo-3-propanol

Downstream raw materials:

1-O-hexadecanoyl-3-O-<<2-(trimethylamino)ethyl>phosphoryl>propanediol

Refernces

• 1、 Ikubo, Masaya,Inoue, Asuka,Nakamura, Sho,Jung, Sejin,Sayama, Misa,Otani, Yuko,Uwamizu, Akiharu,Suzuki, Keisuke,Kishi, Takayuki,Shuto, Akira,Ishiguro, Jun,Okudaira, Michiyo,Kano, Kuniyuki,Makide, Kumiko,Aoki, Junken,Ohwada, Tomohiko. "Structure-activity relationships of lysophosphatidylserine analogs as agonists of G-protein-coupled receptors GPR34, P2Y10, and GPR174". supporting information. p. 4204 - 4219. Retrieved 2015/06/08.
• 2、 Eibl,Westphal. "Palmitoyl-propandiol-(1.3)-phosphorylcholine (2-desoxylysolecithin) and omega.omega'-alkanediol-analogs". . p. 244 - 245. Retrieved 2007/10/07.