N-(3,4-dimethoxybenzyl)-4-methoxyaniline

Base Information

• Chemical Name: N-(3,4-dimethoxybenzyl)-4-methoxyaniline
• CAS No.: 82376-73-6
• Molecular Formula: C16H19NO3
• Molecular Weight: 273.332
• Hs Code.: 2922299090
• European Community (EC) Number: 653-263-4
• ChEMBL ID: CHEMBL1570785
• Mol file: 82376-73-6.mol

Synonyms:N-(3,4-dimethoxybenzyl)-4-methoxyaniline;82376-73-6;N-[(3,4-dimethoxyphenyl)methyl]-4-methoxyaniline;MLS000106634;Cambridge id 5457860;Oprea1_421755;Oprea1_587934;CHEMBL1570785;AKOS000241698;SB81613;SMR000111011;CS-0367733;AG-205/06462044

Chemical Property of N-(3,4-dimethoxybenzyl)-4-methoxyaniline

Chemical Property:

• Melting Point: 114-116 °C
• Boiling Point: 411.5±40.0 °C(Predicted)
• PKA: 4.62±0.35(Predicted)
• PSA: 39.72000
• Density: 1.131±0.06 g/cm3(Predicted)
• LogP: 3.39750
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 273.13649347
• Heavy Atom Count: 20
• Complexity: 266

Purity/Quality:

99% ^*data from raw suppliers

3,4-DIMETHOXY-N-(4-METHOXYPHENYL)BENZYLAMINE Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)NCC2=CC(=C(C=C2)OC)OC

Technology Process of N-(3,4-dimethoxybenzyl)-4-methoxyaniline

There total 7 articles about N-(3,4-dimethoxybenzyl)-4-methoxyaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(3,4-dimethoxybenzylidene)-(4-methoxyphenyl)amine (82363-24-4) → N-(3,4-dimethoxybenzyl)-4-methoxyaniline (82376-73-6)

Guidance literature:

With hydrogen; In acetone; at 50 ℃; for 22h;

Reference yield: 92.0%

4-methoxy-aniline (104-94-9) + 3,4-dimethoxy-benzaldehyde (120-14-9) → N-(3,4-dimethoxybenzyl)-4-methoxyaniline (82376-73-6)

Guidance literature:

4-methoxy-aniline; 3,4-dimethoxy-benzaldehyde; With sodium tris(acetoxy)borohydride; acetic acid; In dichloromethane; at 20 ℃; Inert atmosphere;

With sodium hydrogencarbonate; In dichloromethane; water;

DOI:10.3998/ark.5550190.0012.725

Reference yield: 86.0%

(E)-1-(3,4-dimethoxyphenyl)-N-(4-methoxyphenyl)methanimine (130632-09-6) → N-(3,4-dimethoxybenzyl)-4-methoxyaniline (82376-73-6)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 20 ℃; for 1.16667h;

DOI:10.1016/j.tet.2017.12.049

upstream raw materials:

(3,4-dimethoxybenzylidene)-(4-methoxyphenyl)amine

4-methoxy-aniline

3,4-dimethoxy-benzaldehyde

(E)-1-(3,4-dimethoxyphenyl)-N-(4-methoxyphenyl)methanimine

Downstream raw materials:

C₂₄H₂₇NO₅

1'-(3,4-dimethoxybenzyl)-6'-methoxy-4,4-dimethyl-1',4'-dihydro-2H,2'H,6H-spiro[cyclohexane-1,3'-quinoline]-2,6-dione

N-benzyl-N-(3,4-dimethoxybenzyl)-4-methoxyaniline

N-(3,4-dimethoxybenzyl)-4-methoxy-N-phenethylaniline