3-Chloro-2-fluoro-6-nitrophenol

Base Information

Chemical Name:3-Chloro-2-fluoro-6-nitrophenol
CAS No.:82419-40-7
Molecular Formula:C6H3ClFNO3
Molecular Weight:191.546
Hs Code.:
DSSTox Substance ID:DTXSID60525906
Mol file:82419-40-7.mol

Synonyms:3-chloro-2-fluoro-6-nitrophenol;82419-40-7;Phenol, 3-chloro-2-fluoro-6-nitro-;SCHEMBL11079893;DTXSID60525906;QHXNXZWZWUJJEE-UHFFFAOYSA-N;AMY28428;MFCD28752294;AKOS037645399;AS-60621;CS-0456015;A928623

Suppliers and Price of 3-Chloro-2-fluoro-6-nitrophenol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

AK Scientific
3-chloro-2-fluoro-6-nitrophenol
250mg
$ 131.60

Total 8 raw suppliers

Chemical Property of 3-Chloro-2-fluoro-6-nitrophenol

Chemical Property:

PSA：66.05000
LogP:2.61610
XLogP3:2.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:0
Exact Mass:190.9785488
Heavy Atom Count:12
Complexity:186

Purity/Quality:

97% ^*data from raw suppliers

3-chloro-2-fluoro-6-nitrophenol ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=C(C(=C1[N+](=O)[O-])O)F)Cl

Technology Process of 3-Chloro-2-fluoro-6-nitrophenol

There total 4 articles about 3-Chloro-2-fluoro-6-nitrophenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.5%

: 393-79-3
1,3-dichloro-2-fluoro-4-nitrobenzene

: 82419-40-7
2-fluoro-3-chloro-6-nitrophenol

Guidance literature:: With sodium hydroxide; In chloroform; water; dimethyl sulfoxide;

Reference yield:

: 36556-47-5
3-chloro-1,2-difluorobenzene

: 1805115-08-5
2-fluoro-3-chloro-4-nitrophenol

: C₆H₃ClFNO₃

: 82419-40-7
2-fluoro-3-chloro-6-nitrophenol

Guidance literature:: 3-chloro-1,2-difluorobenzene; With sulfuric acid; nitric acid; at 10 - 20 ℃; for 3h;

With potassium hydroxide; In water; at 20 - 50 ℃; for 6h; Overall yield = 9.49 g;
DOI:10.1007/s11172-021-3327-8

Reference yield:

: 2646-83-5
3,3,4,4-tetrafluorocyclohexene

: 1805115-08-5
2-fluoro-3-chloro-4-nitrophenol

: C₆H₃ClFNO₃

: 82419-40-7
2-fluoro-3-chloro-6-nitrophenol

Guidance literature:: Multi-step reaction with 3 steps

1.1: iron(III) chloride; chlorine / chloroform / 12 h / Heating

2.1: N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide / 7 h / 25 - 90 °C

3.1: sulfuric acid; nitric acid / 3 h / 10 - 20 °C

3.2: 6 h / 20 - 50 °C

With iron(III) chloride; sulfuric acid; N-benzyl-N,N,N-triethylammonium chloride; nitric acid; chlorine; sodium hydroxide; In chloroform;
DOI:10.1007/s11172-021-3327-8