6-Chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridine-3-acetamide

Base Information

• Chemical Name: 6-Chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridine-3-acetamide
• CAS No.: 82626-73-1
• Molecular Formula: C15H11Cl2N3O
• Molecular Weight: 320.17300
• DSSTox Substance ID: DTXSID20517246
• Nikkaji Number: J373.199E
• Wikidata: Q82379142
• Mol file: 82626-73-1.mol

Synonyms:82626-73-1;6-Chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridine-3-acetamide;2-[6-Chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl]acetamide;2-(6-Chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)acetamide;SCHEMBL7261;DTXSID20517246;6-Chloro-2-(4-chlorophenyl)imidazo[1,2-alpha]pyridine-3-acetamide;AKOS030255298;FT-0664659

Chemical Property of 6-Chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridine-3-acetamide

Chemical Property:

• PSA: 61.38000
• Density: 1.47g/cm3
• LogP: 4.48560
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 319.0279174
• Heavy Atom Count: 21
• Complexity: 387

Purity/Quality:

6-Chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridine-3-acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1C2=C(N3C=C(C=CC3=N2)Cl)CC(=O)N)Cl
• Uses: A metabolite of Alpidem A metabolite of Alpidem.

Technology Process of 6-Chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridine-3-acetamide

There total 2 articles about 6-Chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridine-3-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

potassium cyanide (151-50-8) + [6-chloro-2-(4-chlorophenyl)-imidazo[1,2-a]pyridin-3-ylmethyl]-dimethylamine (365213-33-8) → 2-[6-Chloro-2-(4-chloro-phenyl)-imidazo[1,2-a]pyridin-3-yl]-acetamide (82626-73-1) + 2-(6-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)acetonitrile (82626-72-0)

Guidance literature:

[6-chloro-2-(4-chlorophenyl)-imidazo[1,2-a]pyridin-3-ylmethyl]-dimethylamine; With methyl iodide; In dichloromethane; at 20 ℃; for 24h;

potassium cyanide; In water; for 4h; Heating;

Reference yield:

6-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridine (88964-99-2) → 2-[6-Chloro-2-(4-chloro-phenyl)-imidazo[1,2-a]pyridin-3-yl]-acetamide (82626-73-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 77 percent / acetic acid / H₂O / 4 h / 50 - 55 °C

2.1: MeI / CH₂Cl₂ / 24 h / 20 °C

2.2: H₂O / 4 h / Heating

With acetic acid; methyl iodide; In dichloromethane; water;

Reference yield: 85.0%

2-[6-Chloro-2-(4-chloro-phenyl)-imidazo[1,2-a]pyridin-3-yl]-acetamide (82626-73-1) → 2-(6-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)acetic acid (82626-74-2)

Guidance literature:

With potassium hydroxide; In ethanol; for 8h; Heating;

upstream raw materials:

potassium cyanide

[6-chloro-2-(4-chlorophenyl)-imidazo[1,2-a]pyridin-3-ylmethyl]-dimethylamine

6-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridine

Downstream raw materials:

2-(6-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)acetic acid

2-(6-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)-N,N-dimethylacetamide

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