6-Chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridine-3-acetonitrile

Base Information

• Chemical Name: 6-Chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridine-3-acetonitrile
• CAS No.: 82626-72-0
• Molecular Formula: C₁₅H₉Cl₂N₃
• Molecular Weight: 302.163
• DSSTox Substance ID: DTXSID60517245
• Nikkaji Number: J3.666.195J
• Wikidata: Q82379140
• Mol file: 82626-72-0.mol

Synonyms:82626-72-0;6-Chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridine-3-acetonitrile;2-[6-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl]acetonitrile;2-(6-Chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)acetonitrile;6-Chloro-2-(4-chlorophenyl)imidazo[1,2-alpha]pyridine-3-acetonitrile;SCHEMBL7995;DTXSID60517245;AKOS022235576;FT-0664661;[6-Chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl]acetonitrile

Chemical Property of 6-Chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridine-3-acetonitrile

Chemical Property:

• XLogP3: 4.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 301.0173527
• Heavy Atom Count: 20
• Complexity: 386

Purity/Quality:

98% ^*data from raw suppliers

6-Chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridine-3-acetonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC(=CC=C1C2=C(N3C=C(C=CC3=N2)Cl)CC#N)Cl
• Uses: An intermediate for the synthesis of Alpidem.

Technology Process of 6-Chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridine-3-acetonitrile

There total 8 articles about 6-Chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridine-3-acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

5-chloro-2-pyridylamine (1072-98-6) + 4-chlorobenzoylmethyl bromide (536-38-9) + cyanomethyl bromide (590-17-0) → 2-(6-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)acetonitrile (82626-72-0)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h; Irradiation; Sealed tube; Inert atmosphere;

DOI:10.1055/a-1704-4822

Reference yield: 66.0%

S-cyanomethyl O-ethyl carbonodithioate (59463-54-6) + 6-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridine (88964-99-2) → 2-(6-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)acetonitrile (82626-72-0)

Guidance literature:

With tris[2-phenylpyridinato-C₂,N]iridium(III); N,N-dimethyl-formamide; at 24 ℃; regioselective reaction; Inert atmosphere; UV-irradiation;

DOI:10.1016/j.tet.2018.04.079

Reference yield: 42.0%

iodoacetonitrile (624-75-9) + 6-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridine (88964-99-2) → 2-(6-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)acetonitrile (82626-72-0)

Guidance literature:

With fac-tris(2-phenylpyridinato-N,C₂')iridium(III); sodium hydrogencarbonate; In dimethyl sulfoxide; at 20 ℃; for 12h; regioselective reaction; Schlenk technique; Inert atmosphere; Irradiation;

DOI:10.1021/acs.joc.7b00750

upstream raw materials:

potassium cyanide

[6-chloro-2-(4-chlorophenyl)-imidazo[1,2-a]pyridin-3-ylmethyl]-dimethylamine

6-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridine

S-cyanomethyl O-ethyl carbonodithioate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 82626-72-0 6-Chloro-2-(4-chlorophenyl)imidazo[1,2-α]pyridine-3-acetonitrile

Send

Send

Metric Ton KG G Pound L ML

Send

Send