82626-74-2

Basic information

• Product Name: 6-Chloro-2-(4-chlorophenyl)imidazo[1,2-α]pyridine-3-acetic Acid
• Synonyms: [6-Chloro-2-(4-chlorophenyl)imidazo[1,2-α]pyridin-3-yl]acetic Acid;6-Chloro-2-(4-chlorophenyl)imidazo[1,2-α]pyridine-3-acetic Acid;{6-Chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl}acetic Acid
• CAS NO: 82626-74-2
• Molecular Formula: C₁₅H₁₀Cl₂N₂O₂
• Molecular Weight: 321.16
• Product Categories: Aromatics Compounds;Aromatics;Heterocycles
• Mol File: 82626-74-2.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Density: 1.47g/cm³
• Refractive Index: 1.678
• CAS DataBase Reference: 6-Chloro-2-(4-chlorophenyl)imidazo[1,2-α]pyridine-3-acetic Acid(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Chloro-2-(4-chlorophenyl)imidazo[1,2-α]pyridine-3-acetic Acid(82626-74-2)
• EPA Substance Registry System: 6-Chloro-2-(4-chlorophenyl)imidazo[1,2-α]pyridine-3-acetic Acid(82626-74-2)

Safety Data

• Hazardous Substances Data: 82626-74-2(Hazardous Substances Data)

Usage

Chemical Properties

Brown Solid

InChI:InChI=1/C15H10Cl2N2O2/c16-10-3-1-9(2-4-10)15-12(7-14(20)21)19-8-11(17)5-6-13(19)18-15/h1-6,8H,7H2,(H,20,21)

Upstream product

• 88964-99-2 6-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridine 
• 104-88-1 4-chlorobenzaldehyde 
• 89781-40-8 C₁₂H₁₁ClO₃ 
• 99-91-2 para-chloroacetophenone 
• 706-07-0 1-chloro-4-(2-nitrovinyl)benzene 
• 1072-98-6 5-chloro-2-pyridylamine 
• 1381932-40-6 C₁₄H₁₄ClNO₆ 
• 35158-46-4 3-bromo-4-(4-chloro-phenyl)-4-oxo-butyric acid ethyl ester 
• 53503-49-4 ethyl 4-(4-chlorophenyl)-4-oxobutanoate 
• 365213-33-8 [6-chloro-2-(4-chlorophenyl)-imidazo[1,2-a]pyridin-3-ylmethyl]-dimethylamine 
• 82626-73-1 2-[6-Chloro-2-(4-chloro-phenyl)-imidazo[1,2-a]pyridin-3-yl]-acetamide 
• 193979-48-5 ethyl 2-(6-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)acetate 

Downstream Products

• 82625-99-8 2-(6-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)-N,N-dimethylacetamide 
• 946618-38-8 (S)-ethyl-2-{2-[6-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridine-3-yl]acetylamino}-3-(3,4-dihydroxyphenyl)propanoate 
• 946618-48-0 (S)-ethyl-2-{2-[6-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridine-3-yl]acetylamino}-3-[3,4-bis(tert-butyldimethylsilyloxy)phenyl]propanoate 
• 946618-52-6 2-[6-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridine-3-yl]-N-[2-(3,4-di-tert-butyldimethylsilyloxyphenyl)ethyl]acetamide 
• 1257411-86-1 2-(6-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)-N-(1-((2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)acetamide 

Relevant articles and documents

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A series of 6-substituted 2-aryl-N,N-dimethylimidazol [1,2-a]pyridine-3-acetamides, congeners of zolpidem and alpidem, was synthesized and tested in vitro for binding with the benzodiazepine receptor in the competition with 3H-zolpidem as an ω1-selective radioligand. Molecular electrostatic potential (MEP) and the HOMO and LUMO energies were calculated for the compounds by semi-empirical quantum chemistry methods. The lipophilicity parameter of the compounds, expressed as the logarithm of the octanol-water partition coefficient (log P), was calculated; alternatively, standard values of the Hansch hydrophobic substituent constants π were used. In agreement with earlier investigations on the benzodiazepine receptor ligands with a high preference for the ω1-subtype, a quantitative correlation of the biological data with molecular parameters has revealed a significant dependence (r=0.954) of the binding affinity (IC50) on the deepest MEP minimum, in this case associated with the amide carbonyl oxygen atom. The lipophilicity parameters were found to be of lower significance.