82626-72-0

Basic information

• Product Name: 6-Chloro-2-(4-chlorophenyl)imidazo[1,2-α]pyridine-3-acetonitrile
• Synonyms: [6-Chloro-2-(4-chlorophenyl)imidazo[1,2-α]pyridin-3-yl]acetonitrile;6-Chloro-2-(4-chlorophenyl)imidazo[1,2-α]pyridine-3-acetonitrile;{6-Chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl}acetonitrile
• CAS NO: 82626-72-0
• Molecular Formula: C15H9Cl2N3
• Molecular Weight: 302.16
• Product Categories: Aromatics Compounds;Aromatics;Heterocycles
• Mol File: 82626-72-0.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-Chloro-2-(4-chlorophenyl)imidazo[1,2-α]pyridine-3-acetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Chloro-2-(4-chlorophenyl)imidazo[1,2-α]pyridine-3-acetonitrile(82626-72-0)
• EPA Substance Registry System: 6-Chloro-2-(4-chlorophenyl)imidazo[1,2-α]pyridine-3-acetonitrile(82626-72-0)

Safety Data

• Hazardous Substances Data: 82626-72-0(Hazardous Substances Data)

Usage

Chemical Properties

Brown Solid

Uses

An intermediate for the synthesis of Alpidem.

Upstream product

• 1072-98-6 5-chloro-2-pyridylamine 
• 536-38-9 4-chlorobenzoylmethyl bromide 
• 590-17-0 cyanomethyl bromide 
• 624-75-9 iodoacetonitrile 
• 88964-99-2 6-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridine 
• 99-91-2 para-chloroacetophenone 
• 75-05-8 acetonitrile 
• 59463-54-6 S-cyanomethyl O-ethyl carbonodithioate 
• 151-50-8 potassium cyanide 
• 365213-33-8 [6-chloro-2-(4-chlorophenyl)-imidazo[1,2-a]pyridin-3-ylmethyl]-dimethylamine 

Relevant articles and documents

Synthesis of C3-Cyanomethylated Imidazo[1,2- a ]pyridines via Ultrasound-Promoted Three-Component Reaction under Catalyst- and Oxidant-Free Conditions

An efficient synthesis of C3-cyanomethylated imidazo[1,2-α]pyridines via ultrasound-promoted three-component reaction under catalyst-free, oxidant-free, and mild conditions has been developed. A series of C3-cyanomethylated imidazo[1,2-α]pyridines were rapidly prepared with satisfactory yields and good functional group compatibility. This strategy cloud also be applied to the synthesis of zolpidem and alpidem in short steps.

Visible light/Ir(III) photocatalytic initiation of xanthate-based radical-chain reactions: Xanthate group transfer and oxidative addition to aromatic systems

A photocatalyzed redox generation of radicals from O-ethyl xanthates to generate electrophilic radicals under photoredox catalysis, using Ir(ppy)3 and blue LEDs irradiation is described. The protocol can be used in classical xanthate-based inter- and intra-molecular group transfer reactions and oxidative radical addition to several heteroaromatic systems. The process does not require high temperature and reactions are cleaner compared with the traditional peroxide initiation. In the oxidative addition to aromatic systems, the oxidation process is part of the catalytic cycle and does not require a stoichiometric oxidant such as DLP which is particularly difficult to separate from the product.

Iron-Catalyzed Dehydrogenative sp3-sp2 Coupling via Direct Oxidative C-H Activation of Acetonitrile

An iron-catalyzed dehydrogenative sp3-sp2 coupling of acetonitrile and 2-arylimidazo[1,2-a]pyridine has been realized, which can serve as a novel approach toward heteroarylacetonitriles. The merit of this strategy is illustrated by the breadth of functional groups tolerated in the transformation and the fast access to pharmaceuticals (such as zolpidem) directly from the heteroarylacetonitriles.