N-2,3-dihydro-1H-inden-2-yl-N-propylamine

Base Information

• Chemical Name: N-2,3-dihydro-1H-inden-2-yl-N-propylamine
• CAS No.: 82985-09-9
• Molecular Formula: C12H17N
• Molecular Weight: 175.27000
• Mol file: 82985-09-9.mol

Synonyms:2-(N-propyl)aminoindan;2-propylaminoindane oxalate;N-(2,3-dihydro-1H-inden-2-yl)-N-(prop-1-yl)amine;2-(propylamino)-indane;2-N-propylaminoindan;2-(propylamino) indane;Indan-2-yl-propyl-amine;

Chemical Property of N-2,3-dihydro-1H-inden-2-yl-N-propylamine

Chemical Property:

• Melting Point: 173 °C
• Boiling Point: 271.9±29.0 °C(Predicted)
• PKA: 10.00±0.20(Predicted)
• PSA: 12.03000
• Density: 0.98±0.1 g/cm3(Predicted)
• LogP: 2.54430

Purity/Quality:

98%min ^*data from raw suppliers

N-2,3-Dihydro-1H-inden-2-yl-N-propylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-2,3-dihydro-1H-inden-2-yl-N-propylamine

There total 7 articles about N-2,3-dihydro-1H-inden-2-yl-N-propylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(indan-2-yl)propionamide (138006-38-9) → 2-N-n-Propylaminoindan (82985-09-9)

Guidance literature:

With borane; In tetrahydrofuran; diethyl ether; Heating;

DOI:10.1021/jm000087z

Reference yield:

N-Methyl-2-aminoindane (24445-44-1) + N-(indan-2-yl)propionamide (138006-38-9) → 2-N-n-Propylaminoindan (82985-09-9)

Guidance literature:

In tetrahydrofuran;

Reference yield:

2-aminoindane hydrochloride (2338-18-3) → 2-N-n-Propylaminoindan (82985-09-9)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NaHCO₃ / ethyl acetate

2: BH₃ / tetrahydrofuran; diethyl ether / Heating

With borane; sodium hydrogencarbonate; In tetrahydrofuran; diethyl ether; ethyl acetate; 1: Acylation / 2: Reduction;

DOI:10.1021/jm000087z

upstream raw materials:

N-propylamine hydrochloride

2-indanone

N-(indan-2-yl)propionamide

2-aminoindane hydrochloride

Downstream raw materials:

2-amino-6-(N,N-di-n-propylamino)thiazolo[4,5-f]indan

Refernces

• 1、 -. "2-aminothiazol-fused 2-aminoindans and 2-aminotetralins and their use". . . Retrieved 2008/06/13.
• 2、 -. "Pyridazinone derivatives and processes for preparing the same". . . Retrieved 2008/06/13.