GMC-1111 free base

Base Information

Chemical Name:GMC-1111 free base
CAS No.:254885-67-1
Molecular Formula:C₁₆H₂₃N₃S
Molecular Weight:289.445
Hs Code.:
UNII:BT2QU919S1
Nikkaji Number:J1.400.468H
Wikidata:Q27274865
Pharos Ligand ID:RSG68S3R57V8
ChEMBL ID:CHEMBL325710

Synonyms:GMC-1111 free base;UNII-BT2QU919S1;BT2QU919S1;CHEMBL325710;5H-Indeno(5,6-d)thiazole-2,6-diamine, 6,7-dihydro-N6,N6-dipropyl-;254885-67-1;BDBM50092173;L001644;Q27274865;N*6*,N*6*-Dipropyl-6,7-dihydro-5H-1-thia-3-aza-s-indacene-2,6-diamine

Suppliers and Price of GMC-1111 free base

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of GMC-1111 free base

Chemical Property:

XLogP3:4.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:289.16126892
Heavy Atom Count:20
Complexity:319

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCCN(CCC)C1CC2=CC3=C(C=C2C1)SC(=N3)N

Technology Process of GMC-1111 free base

There total 7 articles about GMC-1111 free base which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 333-20-0
potassium thioacyanate

: 162743-13-7
5-amino-2-(N,N-di-n-propylamino)indan

: N⁷,N⁷-dipropyl-7,8-dihydro-6H-1-thia-3-aza-as-indacene-2,7-diamine

: 254885-67-1
2-amino-6-(N,N-di-n-propylamino)thiazolo[4,5-f]indan

Guidance literature:: With bromine; acetic acid; for 1.5h;
DOI:10.1021/jm000087z

Reference yield:

: 82985-09-9
2-N-n-Propylaminoindan

: 254885-67-1
2-amino-6-(N,N-di-n-propylamino)thiazolo[4,5-f]indan

Guidance literature:: Multi-step reaction with 5 steps

1: Et₃N / CH₂Cl₂

2: conc. aq. HNO₃; H₂SO₄ / nitromethane / 1 h / 0 °C

3: 66 percent / NH₄CO₂H / 10percent Pd/C / methanol / 0.75 h / 50 °C

4: 96 percent / BH₃ / diethyl ether; tetrahydrofuran / 1 h / Heating

5: 41 percent / Br₂; glacial acetic acid / 1.5 h

With sulfuric acid; borane; bromine; nitric acid; ammonium formate; acetic acid; triethylamine; 10percent Pd/C; In tetrahydrofuran; methanol; diethyl ether; nitromethane; dichloromethane; 1: Acylation / 2: Nitration / 3: Reduction / 4: Reduction / 5: Cyclization;
DOI:10.1021/jm000087z

Reference yield:

: 2338-18-3
2-aminoindane hydrochloride

: 254885-67-1
2-amino-6-(N,N-di-n-propylamino)thiazolo[4,5-f]indan

Guidance literature:: Multi-step reaction with 7 steps

1: aq. NaHCO₃ / ethyl acetate

2: BH₃ / tetrahydrofuran; diethyl ether / Heating

3: Et₃N / CH₂Cl₂

4: conc. aq. HNO₃; H₂SO₄ / nitromethane / 1 h / 0 °C

5: 66 percent / NH₄CO₂H / 10percent Pd/C / methanol / 0.75 h / 50 °C

6: 96 percent / BH₃ / diethyl ether; tetrahydrofuran / 1 h / Heating

7: 41 percent / Br₂; glacial acetic acid / 1.5 h

With sulfuric acid; borane; bromine; nitric acid; ammonium formate; sodium hydrogencarbonate; acetic acid; triethylamine; 10percent Pd/C; In tetrahydrofuran; methanol; diethyl ether; nitromethane; dichloromethane; ethyl acetate; 1: Acylation / 2: Reduction / 3: Acylation / 4: Nitration / 5: Reduction / 6: Reduction / 7: Cyclization;
DOI:10.1021/jm000087z