C-(4-METHOXY-PHENYL)-C-PHENYL-METHYLAMINE

Base Information

• Chemical Name: C-(4-METHOXY-PHENYL)-C-PHENYL-METHYLAMINE
• CAS No.: 2538-34-3
• Molecular Formula: C14H15 N O
• Molecular Weight: 213.279
• Mol file: 2538-34-3.mol

Synonyms:Benzylamine,p-methoxy-a-phenyl- (6CI,7CI,8CI);(4-Methoxyphenyl)phenylmethanamine; NSC 505711

Chemical Property of C-(4-METHOXY-PHENYL)-C-PHENYL-METHYLAMINE

Chemical Property:

• Vapor Pressure: 5.07E-05mmHg at 25°C
• Refractive Index: 1.581
• Boiling Point: 348.3°Cat760mmHg
• Flash Point: 167.1°C
• PSA: 35.25000
• Density: 1.081g/cm³
• LogP: 3.44360

Purity/Quality:

98%min ^*data from raw suppliers

C-(4-Methoxy-phenyl)-c-phenyl-methylamine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of C-(4-METHOXY-PHENYL)-C-PHENYL-METHYLAMINE

There total 19 articles about C-(4-METHOXY-PHENYL)-C-PHENYL-METHYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

Phenyl N-(4-methoxybenzhydryl)carbamate → 4-methoxybenzhydrylamine (2538-34-3)

Guidance literature:

With lithium hydroxide; water; In acetonitrile; at 50 ℃; for 3h;

DOI:10.1055/s-2000-6391

Reference yield: 100.0%

C22H21NO3 (1309244-68-5) → 4-methoxybenzhydrylamine (2538-34-3)

Guidance literature:

With 7% Pd/C; hydrogen; In methanol; for 1.5h; under 750.075 Torr;

DOI:10.1080/00397911.2010.488798

Reference yield: 96.0%

((4-methoxyphenyl)(phenyl)methyl)triphenylphosphonium trifluoromethanesulfonate → 4-methoxybenzhydrylamine (2538-34-3)

Guidance literature:

With sodium azide; In dimethyl sulfoxide; at 120 ℃; Inert atmosphere; Sealed tube;

DOI:10.1002/anie.202111164

upstream raw materials:

4-Methoxybenzophenone

ammonium formate

(4-methoxyphenyl)(phenyl)methanone oxime

N-trimethylsilyl(4-methoxy)benzaldimine

Downstream raw materials:

4-Methoxybenzophenone

N-benzylidine-1-(4-methoxyphenyl)-1-phenylmethanamine

(R)-2-Fluoro-N-[(R)-(4-methoxy-phenyl)-phenyl-methyl]-2-phenyl-acetamide

(R)-2-Fluoro-N-[(S)-(4-methoxy-phenyl)-phenyl-methyl]-2-phenyl-acetamide

Refernces

• 1、 Babu, K. Naresh,Masarwa, Ahmad,Massarwe, Fedaa,Shioukhi, Israa. "Sequential Selective C?H and C(sp3)?+P Bond Functionalizations: An Entry to Bioactive Arylated Scaffolds". supporting information. p. 26199 - 26209. Retrieved 2021/11/09.
• 2、 Goswami, Pratik P.,Suding, Victoria P.,Carlson, Angela S.,Topczewski, Joseph J.. "Direct Conversion of Aldehydes and Ketones into Azides by Sequential Nucleophilic Addition and Substitution". supporting information. p. 4805 - 4809. Retrieved 2016/10/13.