N-benzylidine-1-(4-methoxyphenyl)-1-phenylmethanamine

Base Information

• Chemical Name: N-benzylidine-1-(4-methoxyphenyl)-1-phenylmethanamine
• CAS No.: 1380114-32-8
• Molecular Formula: C₂₁H₁₉NO
• Molecular Weight: 301.388
• Mol file: 1380114-32-8.mol

Synonyms:N-benzylidine-1-(4-methoxyphenyl)-1-phenylmethanamine

Chemical Property of N-benzylidine-1-(4-methoxyphenyl)-1-phenylmethanamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-benzylidine-1-(4-methoxyphenyl)-1-phenylmethanamine

There total 4 articles about N-benzylidine-1-(4-methoxyphenyl)-1-phenylmethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

1-bromo-4-methoxy-benzene (104-92-7) + N-benzylidene benzylamine (780-25-6) → N-benzylidine-1-(4-methoxyphenyl)-1-phenylmethanamine (1380114-32-8)

Guidance literature:

With palladium diacetate; lithium hexamethyldisilazane; nixantphos; In tetrahydrofuran; at 23 ℃; for 2h; Inert atmosphere; Sealed tube;

DOI:10.1002/adsc.201600075

Reference yield: 83.0%

4-methoxybenzhydrylamine (2538-34-3) + benzaldehyde (100-52-7) → N-benzylidine-1-(4-methoxyphenyl)-1-phenylmethanamine (1380114-32-8)

Guidance literature:

With magnesium sulfate; In dichloromethane; at 20 ℃; for 36h;

DOI:10.1002/chem.201102520

Reference yield:

benzaldehyde (100-52-7) → N-benzylidine-1-(4-methoxyphenyl)-1-phenylmethanamine (1380114-32-8)

Guidance literature:

Multi-step reaction with 2 steps

1: magnesium sulfate / dichloromethane / 24 h / 20 °C / Inert atmosphere

2: palladium diacetate; lithium hexamethyldisilazane; nixantphos / tetrahydrofuran / 2 h / 23 °C / Inert atmosphere; Sealed tube

With palladium diacetate; magnesium sulfate; lithium hexamethyldisilazane; nixantphos; In tetrahydrofuran; dichloromethane;

DOI:10.1002/adsc.201600075

upstream raw materials:

4-methoxybenzhydrylamine

benzaldehyde

1-bromo-4-methoxy-benzene

N-benzylidene benzylamine

Refernces

• 1、 Huang, Li,Zhang, Yu,Staples, Richard J.,Huang, Rui H.,Wulff, William D.. "Double stereodifferentiation in the catalytic asymmetric aziridination of imines prepared from α-chiral amines". supporting information; experimental part. p. 5302 - 5313. Retrieved 2012/05/20.