2-Ethoxy-3-methyl-4-phenylquinoline

Base Information

• Chemical Name: 2-Ethoxy-3-methyl-4-phenylquinoline
• CAS No.: 83463-86-9
• Molecular Formula: C18H17NO
• Molecular Weight: 263.339
• DSSTox Substance ID: DTXSID30395719
• Wikidata: Q82195940
• Mol file: 83463-86-9.mol

Synonyms:2-ethoxy-3-methyl-4-phenylquinoline;83463-86-9;DTXSID30395719

Chemical Property of 2-Ethoxy-3-methyl-4-phenylquinoline

Chemical Property:

• XLogP3: 4.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 263.131014166
• Heavy Atom Count: 20
• Complexity: 300

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC1=NC2=CC=CC=C2C(=C1C)C3=CC=CC=C3

Technology Process of 2-Ethoxy-3-methyl-4-phenylquinoline

There total 9 articles about 2-Ethoxy-3-methyl-4-phenylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

ethanol (64-17-5) + 3-methyl-2-(methylthio)-4-phenylquinoline (1561153-03-4) → 2-ethoxy-3-methyl-4-phenylquinoline (83463-86-9)

Guidance literature:

With sodium hydride; In tetrahydrofuran; ethanol; at 50 ℃; for 24h; Sealed tube; Inert atmosphere;

DOI:10.1021/ol500221u

Reference yield: 57.0%

2-ethoxy-4-hydroxy-3-methyl-4-phenyl-3,4-dihydroquinoline → 2-ethoxy-3-methyl-4-phenylquinoline (83463-86-9)

Guidance literature:

With acetic acid; In ethanol; for 48h; Heating;

Reference yield: 18.0%

2-chloro-3-methyl-4-phenylquinoline (37118-76-6) + sodium ethanolate (141-52-6) → 2-ethoxy-3-methyl-4-phenylquinoline (83463-86-9)

Guidance literature:

In ethanol; for 0.25h; Heating;

DOI:10.1021/jo00146a018

upstream raw materials:

2-chloro-3-methyl-4-phenylquinoline

sodium ethanolate

4-ethoxy-3-methyl-2-phenyl-1,5-benzothiazepine

N-(2-Benzoyl-phenyl)-propionimidic acid ethyl ester