estradiol bis(tert-butyldimethylsilyl)ether

Base Information

Chemical Name:estradiol bis(tert-butyldimethylsilyl)ether
CAS No.:57711-41-8
Molecular Formula:C₃₀H₅₂O₂Si₂
Molecular Weight:500.913
Hs Code.:
Mol file:57711-41-8.mol

Synonyms:estradiol bis(tert-butyldimethylsilyl)ether

Suppliers and Price of estradiol bis(tert-butyldimethylsilyl)ether

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of estradiol bis(tert-butyldimethylsilyl)ether

Chemical Property:

Vapor Pressure:1.48E-09mmHg at 25°C
Boiling Point:497.7°C at 760 mmHg
Flash Point:215.7°C
PSA：18.46000
Density:0.98g/cm³
LogP:9.31710

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of estradiol bis(tert-butyldimethylsilyl)ether

There total 2 articles about estradiol bis(tert-butyldimethylsilyl)ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 50-28-2
estradiol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 57711-41-8
3,17-O-Bis(tert-butyldimethylsilyl)estradiol

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide;
DOI:10.1021/jacs.0c00169

Reference yield: 92.0%

: 1826-67-1
vinyl magnesium bromide

: 168131-85-9
3,17-bis-O-(tert-butyldimethylsilyl)-2-iodo-estradiol

: 57711-41-8
3,17-O-Bis(tert-butyldimethylsilyl)estradiol

: 3,17-bis-(tert-butyl-dimethyl-silanyloxy)-13-methyl-2-vinyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene

Guidance literature:: vinyl magnesium bromide; With zinc dibromide; In tetrahydrofuran;

3,17-bis-O-(tert-butyldimethylsilyl)-2-iodo-estradiol; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; at 20 ℃;
DOI:10.1055/s-1999-2773