Cytidine monophosphate-N-glycoloylneuraminic acid

Base Information

Chemical Name:Cytidine monophosphate-N-glycoloylneuraminic acid
CAS No.:98300-80-2
Molecular Formula:C20H31 N4 O17 P
Molecular Weight:630.456
Hs Code.:
DSSTox Substance ID:DTXSID70904349
Mol file:98300-80-2.mol

Synonyms:CMP-N-glycolylneuraminic acid;CMP-Neu5Gc;cytidine monophosphate-N-glycoloylneuraminic acid

Suppliers and Price of Cytidine monophosphate-N-glycoloylneuraminic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 19 raw suppliers

Chemical Property of Cytidine monophosphate-N-glycoloylneuraminic acid

Chemical Property:

Boiling Point:°Cat760mmHg
Flash Point:°C
PSA：103.12000
Density:2.09g/cm³
LogP:9.44540
XLogP3:-7.4
Hydrogen Bond Donor Count:11
Hydrogen Bond Acceptor Count:17
Rotatable Bond Count:12
Exact Mass:630.14218253
Heavy Atom Count:42
Complexity:1140

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(C(C(OC1(C(=O)O)OP(=O)(O)OCC2C(C(C(O2)N3C=CC(=NC3=O)N)O)O)C(C(CO)O)O)NC(=O)CO)O
Isomeric SMILES:C1[C@@H]([C@H]([C@@H](O[C@@]1(C(=O)O)OP(=O)(O)OC[C@@H]2[C@H]([C@H](C(O2)N3C=CC(=NC3=O)N)O)O)[C@@H]([C@@H](CO)O)O)NC(=O)CO)O

Technology Process of Cytidine monophosphate-N-glycoloylneuraminic acid

There total 15 articles about Cytidine monophosphate-N-glycoloylneuraminic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 113-24-6
sodium pyruvate

: 65-47-4,13191-15-6
cytidine triphosphate

: 2-deoxy-2-[(hydroxyacetyl)amino]-D-mannose

: 98300-80-2
2-O-(cytidin-5'-yloxyphosphoryl)-5-(2-hydroxy-acetamido)-3,5-dideoxy-β-D-glycero-D-galacto-2-nonulopyranosonic acid

Guidance literature:: With Tris-HCl buffer; recombinant sialic acid aldolase; magnesium chloride; recombinant Neisseria meningitidis CMP-Neu₅Ac synthetase; In water; at 37 ℃; pH=8.8;
DOI:10.1016/j.bmc.2004.09.030

Reference yield:

: 80124-69-2
5-glycolylamido-3,5-dideoxy-D-glycero-D-galacto-2-nonulopyranosylonic acid

: 65-47-4,13191-15-6
cytidine triphosphate

: 98300-80-2
2-O-(cytidin-5'-yloxyphosphoryl)-5-(2-hydroxy-acetamido)-3,5-dideoxy-β-D-glycero-D-galacto-2-nonulopyranosonic acid

Guidance literature:: With ST₃-CMPNeu₅Ac-synthetase fusion protein; tris hydrochloride; magnesium chloride; at 20 ℃; for 1h; pH=8.5;
DOI:10.1021/ja017881+

Reference yield:

: 4710-95-6,6730-09-2,14131-59-0,14131-62-5,14131-63-6,14131-65-8,14131-67-0,14257-79-5,19124-46-0,20706-90-5,91673-92-6
D-mannosamine hydrochloride

: 98300-80-2
2-O-(cytidin-5'-yloxyphosphoryl)-5-(2-hydroxy-acetamido)-3,5-dideoxy-β-D-glycero-D-galacto-2-nonulopyranosonic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / triethylamine / methanol / 20 °C

2: 85 percent / Tris-HCl buffer; magnesium chloride; recombinant sialic acid aldolase / recombinant Neisseria meningitidis CMP-Neu₅Ac synthetase / H₂O / 37 °C / pH 8.8

With Tris-HCl buffer; recombinant sialic acid aldolase; triethylamine; magnesium chloride; recombinant Neisseria meningitidis CMP-Neu₅Ac synthetase; In methanol; water;
DOI:10.1016/j.bmc.2004.09.030