Cytidine-5'-triphosphate

Base Information

• Chemical Name: Cytidine-5'-triphosphate
• CAS No.: 65-47-4
• Deprecated CAS: 1259312-99-6,1613528-28-1
• Molecular Formula: C9H16 N3 O14 P3
• Molecular Weight: 483.159
• Hs Code.: HOSPHATE PRODUCT IDENTIFICATION
• European Community (EC) Number: 200-611-4,815-308-8
• UNII: K0118UX80T
• DSSTox Substance ID: DTXSID70889324
• Nikkaji Number: J213.552C
• Wikipedia: Cytidine_triphosphate
• Wikidata: Q409648
• NCI Thesaurus Code: C126896
• Pharos Ligand ID: L62SYDGKBTX6
• Metabolomics Workbench ID: 37065
• ChEMBL ID: CHEMBL223533
• Mol file: 65-47-4.mol

Synonyms:CRPPP;CTP;Cytidine Triphosphate;Magnesium CTP;Mg CTP;Triphosphate, Cytidine

Chemical Property of Cytidine-5'-triphosphate

Chemical Property:

• Appearance/Colour: white powder
• PSA: 299.85000
• LogP: -1.63080
• Storage Temp.: 2-8°C
• XLogP3: -5.6
• Hydrogen Bond Donor Count: 7
• Hydrogen Bond Acceptor Count: 14
• Rotatable Bond Count: 8
• Exact Mass: 482.98451319
• Heavy Atom Count: 29
• Complexity: 855

Purity/Quality:

99% ^*data from raw suppliers

Cytidine Triphosphate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): UN NO.
• Hazard Codes: UN NO.

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Biological Agents -> Nucleic Acids and Derivatives
• Canonical SMILES: C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O
• Isomeric SMILES: C1=CN(C(=O)N=C1N)[C@H]2[C@@H]([C@@H]([C@H](O2)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O
• Recent ClinicalTrials: Effect of Oral Collagen Tripeptide on Skin Moisture and Wrinkles in Adult Women

Technology Process of Cytidine-5'-triphosphate

There total 17 articles about Cytidine-5'-triphosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

cytidine monophosphate (63-37-6,30811-80-4) → cytidine triphosphate (65-47-4,13191-15-6)

Guidance literature:

enzymatic synthesis (adenylate kinase, pyruvate kinase);

Reference yield: 33.0%

cytidine monophosphate (63-37-6,30811-80-4) → cytidine diphosphate (63-38-7) + cytidine triphosphate (65-47-4,13191-15-6)

Guidance literature:

With phosphorotriimidazolide; magnesium chloride; at 22 ℃; for 72h; N-ethylmorpholine buffer (pH 7.0);

DOI:10.1016/S0040-4039(00)74092-5

Reference yield: 13.0%

C9H15N3O15P4 → cytidine triphosphate (65-47-4,13191-15-6)

Guidance literature:

With pyridine; water; iodine; In N,N-dimethyl-formamide; at 20 ℃; for 2.25h;

upstream raw materials:

cytidine monophosphate

UTP

CYTIDINE

cytidine diphosphate

Downstream raw materials:

adenosine(cytidine) 5',5'''-P¹,P⁴-tetraphosphate

CYTIDINE

2-O-(cytidin-5'-yloxyphosphoryl)-5-(2-hydroxy-acetamido)-3,5-dideoxy-β-D-glycero-D-galacto-2-nonulopyranosonic acid

3',5'-cyclic cytidine monophosphate

Refernces

• 1、 McCluskey, Gregory D.,Bearne, Stephen L.. "“Pinching” the ammonia tunnel of CTP synthase unveils coordinated catalytic and allosteric-dependent control of ammonia passage". . p. 2714 - 2727. Retrieved 2018/09/06.
• 2、 Roy, Alexander C.,Lunn, Faylene A.,Bearne, Stephen L.. "Inhibition of CTP synthase from Escherichia coli by xanthines and uric acids". experimental part. p. 141 - 144. Retrieved 2010/04/26.