Spiro[piperidine-4,3'-[3H]pyrrolo[2,3-b]pyridine], 1',2'-dihydro-1'-methyl-1-(phenylmethyl)-

Base Information

• Chemical Name: Spiro[piperidine-4,3'-[3H]pyrrolo[2,3-b]pyridine], 1',2'-dihydro-1'-methyl-1-(phenylmethyl)-
• CAS No.: 845552-79-6
• Molecular Formula: C19H23N3
• Molecular Weight: 293.412
• Mol file: 845552-79-6.mol

Synonyms:

Chemical Property of Spiro[piperidine-4,3'-[3H]pyrrolo[2,3-b]pyridine], 1',2'-dihydro-1'-methyl-1-(phenylmethyl)-

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Spiro[piperidine-4,3'-[3H]pyrrolo[2,3-b]pyridine], 1',2'-dihydro-1'-methyl-1-(phenylmethyl)-

There total 5 articles about Spiro[piperidine-4,3'-[3H]pyrrolo[2,3-b]pyridine], 1',2'-dihydro-1'-methyl-1-(phenylmethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

1-benzyl-1',2'-dihydrospiro[piperidine-4,3'-pyrrolo[2,3-b]-pyridine] (845552-76-3) + methyl iodide (74-88-4) → 1-benzyl-1'-methyl-1',2'-dihydrospiro[piperidine-4,3'-pyrrol[2,3-b]pyridine] (845552-79-6)

Guidance literature:

1-benzyl-1',2'-dihydrospiro[piperidine-4,3'-pyrrolo[2,3-b]-pyridine]; With sodium hydride; In DMF (N,N-dimethyl-formamide); at 0 - 20 ℃; for 0.5h;

methyl iodide; In DMF (N,N-dimethyl-formamide); at 0 - 20 ℃; for 21h;

Reference yield:

2-(2-chloropyridin-3-yl)acetonitrile (101012-32-2) → 1-benzyl-1'-methyl-1',2'-dihydrospiro[piperidine-4,3'-pyrrol[2,3-b]pyridine] (845552-79-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydroxide; cetyltributylphosphonium bromide / water / 1 h / 100 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 15 h / 0 °C / Heating / reflux

3.1: potassium carbonate / acetonitrile / 21 h / Heating / reflux

4.1: sodium hydride / DMF (N,N-dimethyl-formamide) / 0.5 h / 0 - 20 °C

4.2: 21 h / 0 - 20 °C

With sodium hydroxide; lithium aluminium tetrahydride; sodium hydride; cetyltributylphosphonium bromide; potassium carbonate; In tetrahydrofuran; DMF (N,N-dimethyl-formamide); water; acetonitrile;

Reference yield:

1-benzyl-4-(2-chloropyridin-3-yl)piperidine-4-carbonitrile (845552-77-4) → 1-benzyl-1'-methyl-1',2'-dihydrospiro[piperidine-4,3'-pyrrol[2,3-b]pyridine] (845552-79-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 15 h / 0 °C / Heating / reflux

2.1: potassium carbonate / acetonitrile / 21 h / Heating / reflux

3.1: sodium hydride / DMF (N,N-dimethyl-formamide) / 0.5 h / 0 - 20 °C

3.2: 21 h / 0 - 20 °C

With lithium aluminium tetrahydride; sodium hydride; potassium carbonate; In tetrahydrofuran; DMF (N,N-dimethyl-formamide); acetonitrile;

upstream raw materials:

1-benzyl-1',2'-dihydrospiro[piperidine-4,3'-pyrrolo[2,3-b]-pyridine]

methyl iodide

2-(2-chloropyridin-3-yl)acetonitrile

1-benzyl-4-(2-chloropyridin-3-yl)piperidine-4-carbonitrile