845552-76-3

Basic information

• Product Name: Spiro[piperidine-4,3'-[3H]pyrrolo[2,3-b]pyridine], 1',2'-dihydro-1-(phenylMethyl)-
• Synonyms: Spiro[piperidine-4,3'-[3H]pyrrolo[2,3-b]pyridine], 1',2'-dihydro-1-(phenylMethyl)-;1-benzyl-1',2'-dihydrospiro[piperidine-4,3'-pyrrolo[2,3-b]pyridine]
• CAS NO: 845552-76-3
• Molecular Formula: C₁₈H₂₁N₃
• Molecular Weight: 279.37944
• Mol File: 845552-76-3.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: Spiro[piperidine-4,3'-[3H]pyrrolo[2,3-b]pyridine], 1',2'-dihydro-1-(phenylMethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Spiro[piperidine-4,3'-[3H]pyrrolo[2,3-b]pyridine], 1',2'-dihydro-1-(phenylMethyl)-(845552-76-3)
• EPA Substance Registry System: Spiro[piperidine-4,3'-[3H]pyrrolo[2,3-b]pyridine], 1',2'-dihydro-1-(phenylMethyl)-(845552-76-3)

Safety Data

• Hazardous Substances Data: 845552-76-3(Hazardous Substances Data)

Usage

General Description

Spiro[piperidine-4,3'-[3H]pyrrolo[2,3-b]pyridine], 1',2'-dihydro-1-(phenylMethyl)- is a chemical compound with a spirocyclic structure containing a piperidine and pyrrolopyridine ring system. It is also known as 1',2'-dihydro-1-(phenylMethyl)-spiro[piperidine-4,3'-[3H]pyrrolo[2,3-b]pyridine] and is typically used in medicinal chemistry and pharmaceutical research as a building block for the development of new drug candidates. Spiro[piperidine-4,3'-[3H]pyrrolo[2,3-b]pyridine], 1',2'-dihydro-1-(phenylMethyl)- may have potential biological activities due to its unique structural features, and it is of interest for further investigation in drug discovery and development.

Upstream product

• 55-51-6 N,N-bis(2-chloro-ethyl)-benzenemethanamine 
• 845552-77-4 1-benzyl-4-(2-chloropyridin-3-yl)piperidine-4-carbonitrile 
• 101012-32-2 2-(2-chloropyridin-3-yl)acetonitrile 
• 89581-84-0 2-chloro-3-(chloromethyl)pyridine 
• 42330-59-6 (2-chloropyrid-3-yl)methanol 
• 1021303-49-0 C₁₈H₂₂ClN₃ 

Downstream Products

• 845552-79-6 1-benzyl-1'-methyl-1',2'-dihydrospiro[piperidine-4,3'-pyrrol[2,3-b]pyridine] 
• 1606979-88-7 C₁₉H₂₃N₃O₂S 

Relevant articles and documents

Process Development for the Synthesis of a Selective M1 and M4 Muscarinic Acetylcholine Receptors Agonist

A practical and chromatography-free synthetic process to selective M1 and M4 muscarinic acetylcholine receptors agonist was developed and demonstrated on a several hundred gram scale. The key feature of this route is N,N-dimethylcarb

Discovery of N-substituted 7-azaindoline derivatives as potent, orally available M1 and M4 muscarinic acetylcholine receptors selective agonists

We designed and synthesized novel N-substituted 7-azaindoline derivatives as selective M1 and M4 muscarinic acetylcholine receptors (mAChRs) agonists. Hybridization of compound 2 with the HTS hit compound 5 followed by optimization of the N-substituents of 7-azaindoline led to identification of compound 1, which showed highly selective M1 and M4 mAChRs agonistic activity, weak human ether-a-go-go related gene inhibition, and good bioavailability in multiple animal species.