845552-77-4Relevant articles and documents
Process Development for the Synthesis of a Selective M1 and M4 Muscarinic Acetylcholine Receptors Agonist
Uruno, Yoshiharu,Hashimoto, Kazuki,Hiyama, Yoichi,Sumiyoshi, Takaaki
, p. 1610 - 1615 (2017/10/25)
A practical and chromatography-free synthetic process to selective M1 and M4 muscarinic acetylcholine receptors agonist was developed and demonstrated on a several hundred gram scale. The key feature of this route is N,N-dimethylcarb
TETRAHYDROISOQUINOLINE OR ISOCHROMAN COMPOUNDS AS ORL-1 RECEPTOR LIGANDS FOR THE TREATMENT OF PAIN AND CNS DISORDERS
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Page/Page column 55-56, (2010/02/10)
This invention provides the compounds of formula (I), or its a pharmaceutically acceptable ester or amide of such compound, or a pharmaceutically acceptable salt thereof, wherein X1 is NH; R1, R2, R4 through Rs