4-(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)-2-[(formyloxy)methyl]butyl formate (non-preferred name)

Base Information

Chemical Name:4-(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)-2-[(formyloxy)methyl]butyl formate (non-preferred name)
CAS No.:97845-75-5
Molecular Formula:C12H15N5O5
Molecular Weight:309.282
Hs Code.:

Synonyms:

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Chemical Property of 4-(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)-2-[(formyloxy)methyl]butyl formate (non-preferred name)

Chemical Property:

Vapor Pressure:1.94E-15mmHg at 25°C
Boiling Point:622.9°C at 760 mmHg
Flash Point:330.5°C
Density:1.58g/cm³

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4-(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)-2-[(formyloxy)methyl]butyl formate (non-preferred name)

There total 6 articles about 4-(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)-2-[(formyloxy)methyl]butyl formate (non-preferred name) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 64-18-6
formic acid

: 39809-25-1
Penciclovir

: 97845-75-5
9-<4-(formyloxy)-3-<(formyloxy)methyl>but-1-yl>guanine

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; for 0.666667h; Ambient temperature;
DOI:10.1021/jm00392a020

Reference yield:

: 6482-32-2
2-(hydroxymethyl)butane-1,4-diol

: 97845-75-5
9-<4-(formyloxy)-3-<(formyloxy)methyl>but-1-yl>guanine

Guidance literature:: Multi-step reaction with 5 steps

1: 41 percent / p-TsOH*H₂O / tetrahydrofuran / 0.5 h / Ambient temperature

2: 87 percent / CBr₄, PPh₃ / dimethylformamide / 0.5 h / 0 °C

3: 64 percent / K₂CO₃ / dimethylformamide / 5 h / Ambient temperature

4: 72 percent / 2.0 M HCl / 1.25 h / Heating

5: 43 percent / dicyclohexylcarbodiimide, 4-(dimethylamino)pyridine / dimethylformamide / 0.67 h / Ambient temperature

With hydrogenchloride; dmap; carbon tetrabromide; potassium carbonate; toluene-4-sulfonic acid; dicyclohexyl-carbodiimide; triphenylphosphine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm00392a020

Reference yield:

: 7459-46-3
triethyl 1,1,2-ethanetricarboxylate

: 97845-75-5
9-<4-(formyloxy)-3-<(formyloxy)methyl>but-1-yl>guanine

Guidance literature:: Multi-step reaction with 6 steps

1: 100 percent / sodium borohydride, MeOH / 2-methyl-propan-2-ol / 0.5 h / Heating

2: 41 percent / p-TsOH*H₂O / tetrahydrofuran / 0.5 h / Ambient temperature

3: 87 percent / CBr₄, PPh₃ / dimethylformamide / 0.5 h / 0 °C

4: 64 percent / K₂CO₃ / dimethylformamide / 5 h / Ambient temperature

5: 72 percent / 2.0 M HCl / 1.25 h / Heating

6: 43 percent / dicyclohexylcarbodiimide, 4-(dimethylamino)pyridine / dimethylformamide / 0.67 h / Ambient temperature

With hydrogenchloride; methanol; dmap; sodium tetrahydroborate; carbon tetrabromide; potassium carbonate; toluene-4-sulfonic acid; dicyclohexyl-carbodiimide; triphenylphosphine; In tetrahydrofuran; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1021/jm00392a020