1H-Pyrrole-2,3,5-tricarboxylicacid,4-methyl-,3,5-diethylester(9CI)

Base Information

• Chemical Name: 1H-Pyrrole-2,3,5-tricarboxylicacid,4-methyl-,3,5-diethylester(9CI)
• CAS No.: 37789-75-6
• Molecular Formula: C₁₂H₁₅NO₆
• Molecular Weight: 269.254
• Hs Code.: 2933990090
• Mol file: 37789-75-6.mol

Synonyms:1H-Pyrrole-2,3,5-tricarboxylicacid,4-methyl-,3,5-diethylester(9CI)

Chemical Property of 1H-Pyrrole-2,3,5-tricarboxylicacid,4-methyl-,3,5-diethylester(9CI)

Chemical Property:

• Vapor Pressure: 2.19E-10mmHg at 25°C
• Boiling Point: 489.2°Cat760mmHg
• Flash Point: 249.7°C
• PSA: 105.69000
• Density: 1.311g/cm³
• LogP: 1.37470

Purity/Quality:

99% ^*data from raw suppliers

3,5-BIS(ETHOXYCARBONYL)-4-METHYL-1H-PYRROLE-2-CARBOXYLIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Pyrrole-2,3,5-tricarboxylicacid,4-methyl-,3,5-diethylester(9CI)

There total 5 articles about 1H-Pyrrole-2,3,5-tricarboxylicacid,4-methyl-,3,5-diethylester(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diethyl 2,4-dimethylpyrrole-3,5-dicarboxylate (2436-79-5) → diethyl 5-formyl-3-methylpyrrole-2,4-dicarboxylate (2199-60-2) + 3,5-diethoxycarbonyl-4-methylpyrrole-2-carboxylic acid (37789-75-6)

Guidance literature:

With sulfuryl dichloride; bromine; acetic acid; at 10 - 20 ℃;

DOI:10.1007/s00706-008-0034-1

Reference yield:

diethyl 2,4-dimethylpyrrole-3,5-dicarboxylate (2436-79-5) → 3,5-diethoxycarbonyl-4-methylpyrrole-2-carboxylic acid (37789-75-6)

Guidance literature:

With sulfuryl dichloride; bromine; acetic acid; Reagens 4: Acetanhydrid; anschliessend Behandeln mit H₂O;

DOI:10.1021/ja01184a037 DOI:10.1021/ja01258a007

Reference yield:

diethyl 5-formyl-3-methylpyrrole-2,4-dicarboxylate (2199-60-2) → 3,5-diethoxycarbonyl-4-methylpyrrole-2-carboxylic acid (37789-75-6)

Guidance literature:

With potassium permanganate; In water; acetone; at 20 ℃;

DOI:10.1007/s00706-008-0034-1

upstream raw materials:

diethyl 2,4-dimethylpyrrole-3,5-dicarboxylate

4-Methyl-benzoic acid (3aR,4R,6R,6aR)-6-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester

ethyl 2-hydroxyimino-3-oxobutanoate

diethyl 5-formyl-3-methylpyrrole-2,4-dicarboxylate

Downstream raw materials:

diethyl 5-bromo-3-methylpyrrole-2,4-dicarboxylate

5-iodo-3-methyl-pyrrole-2,4-dicarboxylic acid diethyl ester

4-methyl-pyrrole-2,3,5-tricarboxylic acid-3-ethyl ester