2199-60-2

Usage

Uses

Used in Organic Synthesis:
5-FORMYL-3-METHYL-1H-PYRROLE-2,4-DICARBOXYLIC ACID DIETHYL ESTER is used as a key intermediate in organic synthesis for the creation of complex organic molecules. Its presence of ester and formyl groups allows for various chemical reactions, facilitating the synthesis of a wide range of organic compounds.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 5-FORMYL-3-METHYL-1H-PYRROLE-2,4-DICARBOXYLIC ACID DIETHYL ESTER is used as a building block for drug development. Its unique structure and functional groups contribute to the design and synthesis of new pharmaceutical agents, potentially leading to the discovery of novel therapeutics.
Used in Chemical Industry:
5-FORMYL-3-METHYL-1H-PYRROLE-2,4-DICARBOXYLIC ACID DIETHYL ESTER is employed as a versatile reagent in the chemical industry. Its ability to participate in multiple types of chemical reactions makes it suitable for the production of various chemical products, including specialty chemicals and intermediates for further synthesis processes.
Used in Research and Development:
In research and development settings, 5-FORMYL-3-METHYL-1H-PYRROLE-2,4-DICARBOXYLIC ACID DIETHYL ESTER is used as a starting material for exploring new chemical reactions and pathways. Its unique properties and reactivity make it an interesting candidate for studying new synthetic methods and understanding the underlying chemical mechanisms.
Used in Academic and Industrial Laboratories:
5-FORMYL-3-METHYL-1H-PYRROLE-2,4-DICARBOXYLIC ACID DIETHYL ESTER is utilized in academic and industrial laboratories for conducting experiments and developing new methodologies in organic chemistry. Its availability and reactivity make it a popular choice for researchers working on the synthesis of new compounds and the optimization of existing synthetic routes.

InChI:InChI=1/C12H15NO5/c1-4-17-11(15)9-7(3)10(12(16)18-5-2)13-8(9)6-14/h6,13H,4-5H2,1-3H3

Upstream product

• 2436-79-5 diethyl 2,4-dimethylpyrrole-3,5-dicarboxylate 
• 57745-26-3 diethyl 5-(bromomethyl)-3-methylpyrrole-2,4-dicarboxylate 
• 1066-30-4 chromium(lll) acetate 
• 52649-30-6 2-dichloromethyl-3,5-bisethoxycarbonyl-4-methylpyrrole 
• 79830-01-6 5,10-(3,5-bisethoxycarbonyl-4-methylpyrrol-2-ylmethylenedioxy)-1,3,6,8-tetrakisethoxycarbonyl-2,7-dimethyl-5H,10H-dipyrrolo<1,2-a;1',2'-d>pyrazine 
• 5422-89-9 3,5-bisethoxycarbonyl-2-hydroxymethyl-4-methylpyrrole 
• 64-19-7 acetic acid 
• 7647-01-0 hydrogenchloride 

Downstream Products

• 79754-38-4 2-formyl-4-methylpyrrole-3,5-dicarboxylic acid 
• 5448-14-6 4-methyl-3-carbethoxy-5-carboxy-2-formylpyrrole 
• 4458-69-9 diethyl 5-bromo-3-methylpyrrole-2,4-dicarboxylate 
• 5422-89-9 3,5-bisethoxycarbonyl-2-hydroxymethyl-4-methylpyrrole 
• 79754-46-4 3,5-bisethoxycarbonyl-2-formyl-1,4-dimethylpyrrole 
• 124857-23-4 C₂₂H₂₆N₂O₄ 
• 124857-24-5 C₂₆H₃₂N₂O₅ 
• 100129-92-8 diethyl 5-chloro-3-methylpyrrole-2,4-dicarboxylate 
• 625-82-1 2,4-dimethyl-1H-pyrrole 
• 5448-16-8 3-methyl-1H-pyrrole-2,4-dicarboxylic acid diethyl ester 
• 124857-28-9 ethyl 2-<(N-benzyl-N-methylamino)methyl>-3-(ethoxycarbonyl)-4-methylpyrrole-5-carboxylate 
• 124890-68-2 4,1'-Dimethyl-4',5'-diphenyl-1H,1'H-[2,2']bipyrrolyl-3,5,3'-tricarboxylic acid 3'-benzyl ester 3,5-diethyl ester 
• 124857-35-8 4,1'-Dimethyl-3',5'-diphenyl-1H,1'H-[2,2']bipyrrolyl-3,5,4'-tricarboxylic acid 4'-benzyl ester 3,5-diethyl ester 
• 124857-38-1 (2S,3R)-1,4'-Dimethyl-5-phenyl-2,3-dihydro-1H,1'H-[2,2']bipyrrolyl-3,4,3',5'-tetracarboxylic acid 3',5'-diethyl ester 3,4-dimethyl ester 

Relevant academic research and scientific papers

Oxidation of pyrrole α-methyl to formyl with ceric ammonium nitrate

Pyrrole α-aldehydes can be prepared in high yield by oxidation of pyrrole α-methyl groups with ceric ammonium nitrate when the pyrrole ring also has an α-carboxylic acid ester group.

Synthesis and biological evaluation of pyrrolopyridazine derivatives as novel HER-2 tyrosine kinase inhibitors

A series of novel pyrrolopyridazine derivatives have been discovered to be HER-2 inhibitors. These compounds selectively inhibited HER-2 kinase activity at low nanomolar concentrations. Compound 7d was identified as a potent HER-2 inhibitor with an IC50 of 4 nM.

Imploded bilirubins: Synthesis and properties of 10-nor-mesobilirubin- XIIIα and analogs

Six 10-nor-bilirubin analogs have been synthesized and investigated. Lacking the C(10) CH2 group, these linear tetrapyrroles have a bipyrrole core rather than a dipyrrylmethane core and thus a different shape. Whereas the propionic acid groups

Pyrrole Studies. Part 26. A Novel Thermochromic and Photochromic Pyrrole System

2-Dichloromethyl-3,5-bisethoxycarbonyl-4-methylpyrrole (3) yields a thermally labile 5,10-methylenedioxy-5H,10H-dipyrrolopyrazine (1) when heated with 6percent aqueous potassium hydroxide.Upon being heated at 160 deg C the colourless dipyrrolopyrazine is converted into a red bis-(1-azafulvene) system, which can be reconverted photochemically into the dipyrrolopyrazine via a cycloaddition reaction.