3-(ethoxycarbonyl)-4-methyl-1H-pyrrole-2,5-dicarboxylic acid

Base Information

• Chemical Name: 3-(ethoxycarbonyl)-4-methyl-1H-pyrrole-2,5-dicarboxylic acid
• CAS No.: 5448-15-7
• Molecular Formula: C₁₀H₁₁NO₆
• Molecular Weight: 241.2
• Mol file: 5448-15-7.mol

Synonyms:Pyrrole-2,3,5-tricarboxylicacid, 4-methyl-, 3-ethyl ester (7CI); NSC 17443

Chemical Property of 3-(ethoxycarbonyl)-4-methyl-1H-pyrrole-2,5-dicarboxylic acid

Chemical Property:

• Vapor Pressure: 8.01E-14mmHg at 25°C
• Boiling Point: 569.8°Cat760mmHg
• Flash Point: 298.4°C
• Density: 1.475g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(ethoxycarbonyl)-4-methyl-1H-pyrrole-2,5-dicarboxylic acid

There total 4 articles about 3-(ethoxycarbonyl)-4-methyl-1H-pyrrole-2,5-dicarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,5-diethoxycarbonyl-4-methylpyrrole-2-carboxylic acid (37789-75-6) → 4-methyl-pyrrole-2,3,5-tricarboxylic acid-3-ethyl ester (5448-15-7)

Guidance literature:

With sulfuric acid;

DOI:10.1021/ja01189a041

Reference yield:

diethyl 2,4-dimethylpyrrole-3,5-dicarboxylate (2436-79-5) → 4-methyl-pyrrole-2,3,5-tricarboxylic acid-3-ethyl ester (5448-15-7)

Guidance literature:

Multi-step reaction with 2 steps

1: bromine; SO₂Cl₂; acetic acid / Reagens 4: Acetanhydrid; anschliessend Behandeln mit H₂O

2: aqueous NaOH

With sodium hydroxide; sulfuryl dichloride; bromine; acetic acid;

DOI:10.1021/ja01184a037

Reference yield:

3,5-diethoxycarbonyl-4-methylpyrrole-2-carboxylic acid (37789-75-6) → 4-methyl-pyrrole-2,3,5-tricarboxylic acid-3-ethyl ester (5448-15-7)

Guidance literature:

at 75 ℃;

DOI:10.1021/ja01189a041

upstream raw materials:

3,5-diethoxycarbonyl-4-methylpyrrole-2-carboxylic acid

sulfuric acid

diethyl 2,4-dimethylpyrrole-3,5-dicarboxylate

Downstream raw materials:

2,5-diiodo-4-methyl-pyrrole-3-carboxylic acid ethyl ester

ethyl 4-methylpyrrole-3-carboxylate