Ethyl 1,1,2,2-tetrafluoroethyl ether

Base Information

• Chemical Name: Ethyl 1,1,2,2-tetrafluoroethyl ether
• CAS No.: 512-51-6
• Molecular Formula: C4H6F4O
• Molecular Weight: 146.085
• Hs Code.: 2909199090
• European Community (EC) Number: 680-776-0
• DSSTox Substance ID: DTXSID4075249
• Nikkaji Number: J969.391B
• Wikidata: Q66084490
• Mol file: 512-51-6.mol

Synonyms:512-51-6;Ethyl 1,1,2,2-tetrafluoroethyl ether;1-Ethoxy-1,1,2,2-tetrafluoroethane;1,1,2,2-tetrafluoroethyl ethyl ether;374pcE-beta-gamma;C4H6F4O;Ethane, 1-ethoxy-1,1,2,2-tetrafluoro-;Ether, ethyl 1,1,2,2-tetrafluoroethyl;SCHEMBL658787;DTXSID4075249;1,1,2,2-tetrafluoroethyl ether;1,1,2,2-Tetrafluoroethoxyethane;Ethoxy-1,1,2,2-tetrafluoroethane;1,1,2,2-Tetrafluoro Ethyl Ether;MFCD00069162;ethyl1,1,2,2-tetrafluoroethyl ether;AKOS005063427;ethyl-1,1,2,2-tetrafluoroethyl ether;1,1,2,2-Tetrafluoroethyl ether, 97%;LS-65566;MS-20255;E1019;FT-0625825;D90583;ethyl 1,1,2,2-tetrafluoroethyl ether/HFE-374E

Chemical Property of Ethyl 1,1,2,2-tetrafluoroethyl ether

Chemical Property:

• Vapor Pressure: 0.037mmHg at 25°C
• Refractive Index: 1.496
• Boiling Point: 57.5 °C
• Flash Point: 56-58°C
• PSA: 9.23000
• Density: 1.198
• LogP: 1.88080
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 146.03547746
• Heavy Atom Count: 9
• Complexity: 82.6

Purity/Quality:

99% ^*data from raw suppliers

Ethyl 1,1,2,2-Tetrafluoroethyl Ether ^*data from reagent suppliers

Safty Information:

• Pictogram(s): FXi
• Hazard Codes: F,Xi
• Statements: 11
• Safety Statements: 16-23-33

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(C(F)F)(F)F

Technology Process of Ethyl 1,1,2,2-tetrafluoroethyl ether

There total 3 articles about Ethyl 1,1,2,2-tetrafluoroethyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethanol (64-17-5) + 2-chloro-1,1,2,2-tetrafluoroethane (354-25-6) → Ethyl 1,1,2,2-tetrafluoroethyl ether (512-51-6)

Guidance literature:

With potassium hydroxide; at 120 ℃;

DOI:10.1021/ja01160a531

Reference yield:

polytetrafluoroethylene (116-14-3,82785-14-6) + sodium ethanolate (141-52-6) → Ethyl 1,1,2,2-tetrafluoroethyl ether (512-51-6)

Guidance literature:

at 50 ℃;

DOI:10.1021/ja01181a526

Reference yield:

→ Ethyl 1,1,2,2-tetrafluoroethyl ether (512-51-6)

Guidance literature:

1,2-Dibrom-tetrafluoraethan, KOH, EtOH (S. 126, 137);

DOI:10.1016/S0022-1139(00)81081-7

upstream raw materials:

ethanol

2-chloro-1,1,2,2-tetrafluoroethane

polytetrafluoroethylene

sodium ethanolate

Downstream raw materials:

(1-chloro-ethyl)-(1,1,2,2-tetrafluoro-ethyl)-ether

(2-chloro-ethyl)-(1,1,2,2-tetrafluoro-ethyl)-ether

ethyl difluoroacetate

ethyl 4,4-difluoro-3-oxo-2-piperidin-1-ylmethylbutyrate

Refernces

• 1、 -. "Preparation of difluoroacetic acid fluoride and difluoroacetic acid esters". . . Retrieved 2008/06/13.