(3S,8aS)-3-Isobutyloctahydropyrrolo[1,2-a]pyrazine

Base Information

• Chemical Name: (3S,8aS)-3-Isobutyloctahydropyrrolo[1,2-a]pyrazine
• CAS No.: 1072102-31-8
• Molecular Formula: C11H22N2
• Molecular Weight: 182.30578
• Hs Code.: 2933998090
• Mol file: 1072102-31-8.mol

Synonyms:(3S,6S)-3-Isobutyl-1,4-diazabicyclo[4.3.0]nonane;(3S,8aS)-3-Isobutyloctahydropyrrolo[1,2-a]pyrazine

Chemical Property of (3S,8aS)-3-Isobutyloctahydropyrrolo[1,2-a]pyrazine

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

(3S,6S)-3-Isobutyl-1,4-diazabicyclo[4.3.0]nonane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3S,8aS)-3-Isobutyloctahydropyrrolo[1,2-a]pyrazine

There total 6 articles about (3S,8aS)-3-Isobutyloctahydropyrrolo[1,2-a]pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

cyclo(L-Pro-L-Leu) (2873-36-1) → (3S,8aS)-3-isobutyloctahydropyrrolo[1,2-a]pyrazine (1072102-31-8)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; Reflux;

DOI:10.1039/b904254g

Reference yield:

3-(2-methylpropyl)hexahydropyrrolo[1,2-a]pyrazin-1,4-dione (274680-11-4) → C11H22N2 (1261569-83-8,1072102-31-8)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 3h; Reflux;

DOI:10.1016/j.bmcl.2010.10.061

Reference yield:

(3S,8aR)-3-isobutyl-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione (2873-36-1,5654-86-4,19943-30-7,32510-93-3,36238-67-2,43041-29-8) → (8aR)-3c-isobutyl-(8ar)-octahydro-pyrrolo[1,2-a]pyrazine (1072102-31-8)

Guidance literature:

With lithium aluminium tetrahydride; diethyl ether;

DOI:10.1093/imanum/20.4.499

upstream raw materials:

(3S,8aR)-3-isobutyl-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione

cyclo(L-Pro-L-Leu)

Z-Leu-OH

N-(benzyloxycarbonyl)-L-leucyl-L-proline methyl ester

Downstream raw materials:

C₂₈H₄₁N₃O₂

(3R,9R)-2-{[1-(Cyclohexylmethyl)-7-methoxy-1H-indol-3-yl]carbonyl}-3-isobutyloctahydro-2H-pyrrolo[1,2-a]pyrazine

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