3-Thiophenecarboxylic acid, 2-amino-5-[(2,4-dimethoxyphenyl)methyl]-, ethyl ester

Base Information

Chemical Name:3-Thiophenecarboxylic acid, 2-amino-5-[(2,4-dimethoxyphenyl)methyl]-, ethyl ester
CAS No.:848081-13-0
Molecular Formula:C16H19NO4S
Molecular Weight:321.397
Hs Code.:

Synonyms:

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Chemical Property of 3-Thiophenecarboxylic acid, 2-amino-5-[(2,4-dimethoxyphenyl)methyl]-, ethyl ester

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Technology Process of 3-Thiophenecarboxylic acid, 2-amino-5-[(2,4-dimethoxyphenyl)methyl]-, ethyl ester

There total 2 articles about 3-Thiophenecarboxylic acid, 2-amino-5-[(2,4-dimethoxyphenyl)methyl]-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 105-56-6
ethyl 2-cyanoacetate

: 848081-07-2
3-(2',4'-dimethoxyphenyl)propionaldehyde

: 848081-13-0
2-amino-5-(2',4'-dimethoxybenzyl)thiophene-3-carboxylic acid ethyl ester

Guidance literature:: With sulfur; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 2h;
DOI:10.1002/jhet.5570410613

Reference yield:

: 20469-63-0
1-iodo-2,4-dimethoxybenzene

: 848081-13-0
2-amino-5-(2',4'-dimethoxybenzyl)thiophene-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / palladium diacetate; aq. tetrabutylammonium chloride; sodium bicarbonate / 30 h / 80 °C

2: 33 percent / triethylamine; sulfur powd. / dimethylformamide / 2 h / 20 °C

With tetrabutyl-ammonium chloride; palladium diacetate; sodium hydrogencarbonate; sulfur; triethylamine; In N,N-dimethyl-formamide;
DOI:10.1002/jhet.5570410613