5-Pyrimidinecarboxylic acid, 1,2-dihydro-4-methyl-2-oxo-6-phenyl-, methyl ester

Base Information

Chemical Name:5-Pyrimidinecarboxylic acid, 1,2-dihydro-4-methyl-2-oxo-6-phenyl-, methyl ester
CAS No.:848301-50-8
Molecular Formula:C13H12N2O3
Molecular Weight:244.25
Hs Code.:

Synonyms:6-Methyl-2-oxo-4-phenyl-1,2-dihydro-pyrimidine-5-carboxylic acid methyl ester;4-phenyl-6-methyl-pyrimidin-2(1H)-one-5-carboxylic acid methyl ester;

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Chemical Property of 5-Pyrimidinecarboxylic acid, 1,2-dihydro-4-methyl-2-oxo-6-phenyl-, methyl ester

Chemical Property:

PSA：72.05000
LogP:1.53190

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 5-Pyrimidinecarboxylic acid, 1,2-dihydro-4-methyl-2-oxo-6-phenyl-, methyl ester

There total 4 articles about 5-Pyrimidinecarboxylic acid, 1,2-dihydro-4-methyl-2-oxo-6-phenyl-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 188780-24-7
5-methoxycarbonyl-6-methyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-one

: 848301-50-8
6-methyl-2-oxo-4-phenyl-1,2-dihydropyrimidine-5-carboxylic acid methyl ester

Guidance literature:: With quinolinium chlorochromate(VI); In dichloromethane;

Reference yield:

: 100-52-7
benzaldehyde

: 105-45-3
acetoacetic acid methyl ester

: 848301-50-8
6-methyl-2-oxo-4-phenyl-1,2-dihydropyrimidine-5-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: copper(II) bis(trifluoromethanesulfonate) / ethanol / 2.5 h / 100 °C / Microwave irradiation; Sealed tube

2: ammonium cerium (IV) nitrate / water; dimethyl sulfoxide; acetone / 21 h / -5 - 20 °C

With ammonium cerium (IV) nitrate; copper(II) bis(trifluoromethanesulfonate); In ethanol; water; dimethyl sulfoxide; acetone; 1: |Biginelli Pyrimidone Synthesis;
DOI:10.1039/d0ra10255e

Reference yield:

: 105-45-3
acetoacetic acid methyl ester

: 848301-50-8
6-methyl-2-oxo-4-phenyl-1,2-dihydropyrimidine-5-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium chloride / 3 h / 100 °C

2: nitric acid / 0.5 h / 0 °C

With nitric acid; ammonium chloride; 1: |Biginelli Pyrimidone Synthesis;
DOI:10.1016/j.ejmech.2013.05.046