3-(Cyclopropylmethoxy)-4-hydroxybenzoic acid methyl ester

Base Information

• Chemical Name: 3-(Cyclopropylmethoxy)-4-hydroxybenzoic acid methyl ester
• CAS No.: 848574-60-7
• Molecular Formula: C₁₂H₁₄O₄
• Molecular Weight: 222.241
• Hs Code.: 2918990090
• Mol file: 848574-60-7.mol

Synonyms:3-(Cyclopropylmethoxy)-4-hydroxybenzoic acid methyl ester;

Chemical Property of 3-(Cyclopropylmethoxy)-4-hydroxybenzoic acid methyl ester

Chemical Property:

• PSA: 55.76000
• Density: 1.241
• LogP: 1.96760
• Storage Temp.: 2-8°C
• Solubility.: DCM, Ethyl Acetate, Methanol

Purity/Quality:

99% ^*data from raw suppliers

3-(Cyclopropylmethoxy)-3-hydroxybenzoicAcidMethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-(Cyclopropylmethoxy)-3-hydroxybenzoic Acid Methyl Ester is an intermediate in the synthesis of Roflumilast (R639700), an selective phosphodiesterase 4(PDE4) inhibitor.

Technology Process of 3-(Cyclopropylmethoxy)-4-hydroxybenzoic acid methyl ester

There total 14 articles about 3-(Cyclopropylmethoxy)-4-hydroxybenzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methanol (67-56-1) + 3-(cyclopropylmethoxy)-4-hydroxybenzoic acid (1243391-44-7) → 3-cyclopropylmethoxy-4-hydroxybenzoic acid methyl ester (848574-60-7)

Guidance literature:

With thionyl chloride; at 50 ℃; for 3h;

DOI:10.1055/s-0032-1317527

Reference yield: 99.0%

4-benzyloxy-3-cyclopropylmethoxybenzoic acid methyl ester (1255707-32-4) → 3-cyclopropylmethoxy-4-hydroxybenzoic acid methyl ester (848574-60-7)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; for 18h;

Reference yield: 92.4%

methyl 3,4-bis(cyclopropylmethoxy)benzoate → 3-cyclopropylmethoxy-4-hydroxybenzoic acid methyl ester (848574-60-7)

Guidance literature:

With sodium thioethylate; In N,N-dimethyl-formamide; at 80 ℃; for 8h; Solvent; Reagent/catalyst; Temperature;

upstream raw materials:

3,4-dihydroxybenzoic acid methyl ester

cyclopropylcarbinyl bromide

methanol

3-(cyclopropylmethoxy)-4-hydroxybenzoic acid

Downstream raw materials:

C₂₅H₂₇FO₈

C₃₇H₄₀O₁₂