N-ethyl-N-(pyridin-2-ylmethyl)ethanamine

Base Information

• Chemical Name: N-ethyl-N-(pyridin-2-ylmethyl)ethanamine
• CAS No.: 17751-50-7
• Molecular Formula: C10H16 N2
• Molecular Weight: 164.25
• Mol file: 17751-50-7.mol

Synonyms:Pyridine,2-[(diethylamino)methyl]- (8CI); NSC 77099

Chemical Property of N-ethyl-N-(pyridin-2-ylmethyl)ethanamine

Chemical Property:

• Vapor Pressure: 0.156mmHg at 25°C
• Boiling Point: 214.4°Cat760mmHg
• Flash Point: 83.5°C
• Density: 0.953g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-ethyl-N-(pyridin-2-ylmethyl)ethanamine

There total 6 articles about N-ethyl-N-(pyridin-2-ylmethyl)ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2-chloromethylpyridine hydrochloride (6959-47-3) + diethylamine (109-89-7) → N-ethyl-N-(pyridin-2-ylmethyl)ethanamine (17751-50-7)

Guidance literature:

With potassium carbonate; sodium iodide; In acetonitrile; at 20 ℃; for 12h; Inert atmosphere;

DOI:10.1021/acs.orglett.5b02898

Reference yield: 80.0%

acetylene (74-86-2,25067-58-7) + diethylaminoacetonitrile (3010-02-4) → N-ethyl-N-(pyridin-2-ylmethyl)ethanamine (17751-50-7)

Guidance literature:

With cobaltocene; In tetrahydrofuran; at 150 ℃; for 3h; under 10640 Torr;

Reference yield: 72.0%

2-(phenylsulfonyl)pyridine (24244-60-8) + N-<(trimethylsilyl)methyl>-N,N-diethylamine (10545-36-5) → N-ethyl-N-(pyridin-2-ylmethyl)ethanamine (17751-50-7)

Guidance literature:

With Eosin Y; In methanol; acetonitrile; at 20 ℃; for 3h; Irradiation;

DOI:10.1002/chem.202102124

upstream raw materials:

pyridine-2-carbaldehyde

diethylamine

acetylene

diethylaminoacetonitrile

Downstream raw materials:

N-ethyl-N-(phenyl(pyridin-2-yl)methyl)ethanamine

Refernces

• 1、 Dyer, Robert M. B.,Hahn, Philip L.,Hilinski, Michael K.. "Selective Heteroaryl N-Oxidation of Amine-Containing Molecules". supporting information. p. 2011 - 2014. Retrieved 2018/04/16.
• 2、 Kim, Byeong-Seon,Jiménez, Jacqueline,Gao, Feng,Walsh, Patrick J.. "Palladium-Catalyzed Benzylic C-H Arylation of Azaarylmethylamines". supporting information. p. 5788 - 5791. Retrieved 2015/12/11.