2(5H)-Furanone, 4-bromo-3-[hydroxy(4-methoxyphenyl)methyl]-

Base Information

Chemical Name:2(5H)-Furanone, 4-bromo-3-[hydroxy(4-methoxyphenyl)methyl]-
CAS No.:849024-38-0
Molecular Formula:C12H11BrO4
Molecular Weight:299.121
Hs Code.:

Synonyms:

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Chemical Property of 2(5H)-Furanone, 4-bromo-3-[hydroxy(4-methoxyphenyl)methyl]-

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Technology Process of 2(5H)-Furanone, 4-bromo-3-[hydroxy(4-methoxyphenyl)methyl]-

There total 1 articles about 2(5H)-Furanone, 4-bromo-3-[hydroxy(4-methoxyphenyl)methyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 56634-50-5
4-bromo-5H-furan-2-one

: 123-11-5
4-methoxy-benzaldehyde

: 849024-38-0
4-bromo-3-[hydroxy-(4-methoxy-phenyl)-methyl]-5H-furan-2-one

Guidance literature:: With 2,6-dimethylpyridine; di-n-butylboryl trifluoromethanesulfonate; In tetrahydrofuran; at -78 - -20 ℃; for 0.75h;
DOI:10.1055/s-2004-837220

Reference yield: 86.0%

: 5720-07-0
4-methoxyphenylboronic acid

: 849024-38-0
4-bromo-3-[hydroxy-(4-methoxy-phenyl)-methyl]-5H-furan-2-one

: 849024-39-1
3-[hydroxy-(4-methoxy-phenyl)-methyl]-4-(4-methoxy-phenyl)-5H-furan-2-one

Guidance literature:: With triphenyl-arsane; silver(l) oxide; bis(benzonitrile)palladium(II) dichloride; In tetrahydrofuran; at 23 ℃; for 20h;
DOI:10.1055/s-2004-837220

Reference yield:

: 849024-38-0
4-bromo-3-[hydroxy-(4-methoxy-phenyl)-methyl]-5H-furan-2-one

: (Z)-3-(3,5-dibromo-4-hydroxybenzoyl)-5-(3,5-dibromo-4-hydroxybenzylidene)-4-(3,5-dibromo-4-hydroxyphenyl)furan-2(5H)-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: 86 percent / aq. AsPh₃; Ag₂O / PdCl₂(PhCN)2 / tetrahydrofuran / 20 h / 23 °C

2.1: 89 percent / Dess-Martin periodinane / CH₂Cl₂ / 15 h / 23 °C

3.1: TBSOTf; i-Pr₂NEt / CH₂Cl₂ / 1 h / 23 °C

3.2: 94 percent / DBU / CH₂Cl₂ / 2 h / 23 °C

4.1: 93 percent / BBr₃ / CH₂Cl₂ / 20 h / -78 - 23 °C

5.1: 98 percent / Br₂; aq. KBr / dioxane / 1 h / 23 °C

With triphenyl-arsane; t-butyldimethylsiyl triflate; bromine; boron tribromide; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; potassium bromide; silver(l) oxide; bis(benzonitrile)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; dichloromethane;
DOI:10.1055/s-2004-837220