Technology Process of Carbamic acid,
[(1S)-1-[2-fluoro-2-oxo-1-[(phenylmethoxy)methoxy]ethyl]-3-methylbutyl]-,
1,1-dimethylethyl ester
There total 1 articles about Carbamic acid,
[(1S)-1-[2-fluoro-2-oxo-1-[(phenylmethoxy)methoxy]ethyl]-3-methylbutyl]-,
1,1-dimethylethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
diethylamino-sulfur trifluoride;
In
dichloromethane;
at 0 - 10 ℃;
for 4h;
- Guidance literature:
-
With
dmap;
In
toluene;
at 85 ℃;
for 5.5h;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: dmap / toluene / 5.5 h / 85 °C
2: hydrogenchloride; hydrogen / palladium 10% on activated carbon / tetrahydrofuran; water / 21 h
3: dmap; triethylamine / dichloromethane / 6 h
4: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane
5: sodium tetrahydroborate / methanol; ethanol / 3 h / 0 - 20 °C
6: dmap; triethylamine / dichloromethane / 19 h
7: 10-camphorsufonic acid / methanol; dichloromethane / 4 h / 20 °C
With
hydrogenchloride; dmap; sodium tetrahydroborate; tetrapropylammonium perruthennate; 10-camphorsufonic acid; hydrogen; 4-methylmorpholine N-oxide; triethylamine;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water; toluene;
