ethyl 2-benzoylbutanoate

Base Information

• Chemical Name: ethyl 2-benzoylbutanoate
• CAS No.: 24346-56-3
• Molecular Formula: C13H16 O3
• Molecular Weight: 220.268
• Mol file: 24346-56-3.mol

Synonyms:Butyricacid, 2-benzoyl-, ethyl ester (7CI,8CI); 2-Carbethoxybutyrophenone; Ethyl2-benzoylbutyrate; NSC 265359

Chemical Property of ethyl 2-benzoylbutanoate

Chemical Property:

• Vapor Pressure: 0.00144mmHg at 25°C
• Boiling Point: 296.3°C at 760 mmHg
• Flash Point: 125.9°C
• Density: 1.062g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl 2-benzoylbutanoate

There total 35 articles about ethyl 2-benzoylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

1-Ethoxy-1-trimethylsilyloxy-1-buten (65946-52-3) + benzoyl chloride (98-88-4) → 2-benzoyl-butyric acid ethyl ester (24346-56-3)

Guidance literature:

With copper(l) chloride; In various solvent(s); for 13h; Ambient temperature;

DOI:10.1016/S0040-4039(98)01334-3

Reference yield: 86.0%

diethylzinc (557-20-0) + ethyl 3-oxo-3-phenylpropionate (94-02-0) → 2-benzoyl-butyric acid ethyl ester (24346-56-3)

Guidance literature:

With [hydroxy(tosyloxy)iodo]benzene; magnesium sulfate; ethanolamine; In toluene; at -78 ℃; for 18h; Inert atmosphere; Darkness;

DOI:10.1021/ol503384c

Reference yield: 63.0%

N,N-phenyl-p-toluenesulfonylbenzamide (74542-54-4) + butanoic acid ethyl ester (105-54-4) → 2-benzoyl-butyric acid ethyl ester (24346-56-3)

Guidance literature:

With lithium hexamethyldisilazane; In tetrahydrofuran; at 25 ℃; for 2h; chemoselective reaction; Inert atmosphere; Green chemistry;

DOI:10.1021/acs.joc.0c02868

upstream raw materials:

2-ethyl-3-oxo-acrylic acid ethyl ester

ethyl 2-ethyl-4-methyl-3-oxopentanoate

benzoic acid ethyl ester

2-ethyl-3-oxo-3-phenylpropanenitrile

Downstream raw materials:

2-benzoyl-2-piperidinomethyl-butyric acid ethyl ester

4-ethyl-2-(2-diethylamino-ethyl)-5-phenyl-1,2-dihydro-pyrazol-3-one

5-ethyl-2,6-diphenyl-3H-pyrimidin-4-one

4-ethyl-5-phenyl-3H-1,2-dithiole-3-thione