Oxirane, ((1-naphthalenyloxy)methyl)-, (S)-

Base Information

Chemical Name:Oxirane, ((1-naphthalenyloxy)methyl)-, (S)-
CAS No.:61249-00-1
Molecular Formula:C13H12 O2
Molecular Weight:200.237
Hs Code.:
European Community (EC) Number:612-105-4
UNII:212652A7IH
DSSTox Substance ID:DTXSID10210153
Nikkaji Number:J534.799H
Wikidata:Q27253503
Mol file:61249-00-1.mol

Synonyms:61249-00-1;Oxirane, ((1-naphthalenyloxy)methyl)-, (S)-;(S)-Glycidyl 1-naphthyl ether;Glycidyl 1-naphthyl ether, (S)-;CCRIS 6392;(2S)-2-(naphthalen-1-yloxymethyl)oxirane;(S)-(+)-Glycidyl 1-naphthyl ether;(S)-((1-Naphthalenyloxy)methyl)oxirane;(2S)-2-[(1-Naphthalenyloxy)methyl]oxirane;UNII-212652A7IH;(S)-2-((NAPHTHALEN-1-YLOXY)METHYL)OXIRANE;212652A7IH;(2S)-2-[(NAPHTHALEN-1-YLOXY)METHYL]OXIRANE;(S)-1-(1-Naphthyloxy)-2,3-epoxypropane;Oxirane, [(naphthalenyloxy)methyl]-, (2S)-;SCHEMBL5433989;DTXSID10210153;(S)-(+)-glycidyl naphthyl ether;S-(+)-?-Naphthyl Glycidyl Ether;[(S)-Glycidyl](1-naphthyl) ether;MFCD01709481;(S)-1-(2,3-epoxypropoxy)naphthalene;1-NAPHTHYL (S)-GLYCIDYL ETHER;AT28512;S-(+)- alpha -Naphthyl Glycidyl Ether;LS-101088;S-(+)-ALPHA-NAPHTHYL GLYCIDYL ETHER;.ALPHA.-NAPHTHYL GLYCIDYL ETHER, (+)-;Q27253503

Suppliers and Price of Oxirane, ((1-naphthalenyloxy)methyl)-, (S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
S-(+)-α-NaphthylGlycidylEther
100mg
$ 175.00

TRC
S-(+)-α-NaphthylGlycidylEther
1g
$ 1355.00

American Custom Chemicals Corporation
OXIRANE, ((1-NAPHTHALENYLOXY)METHYL)-, (S)- 95.00%
5MG
$ 497.77

Total 4 raw suppliers

Chemical Property of Oxirane, ((1-naphthalenyloxy)methyl)-, (S)-

Chemical Property:

PSA：21.76000
LogP:2.61740
Storage Temp.:-20?C Freezer
Solubility.:Chloroform (Slightly), Methanol (Sparingly)
XLogP3:3.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:200.083729621
Heavy Atom Count:15
Complexity:217

Purity/Quality:

97% ^*data from raw suppliers

S-(+)-α-NaphthylGlycidylEther ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(O1)COC2=CC=CC3=CC=CC=C32
Isomeric SMILES:C1[C@H](O1)COC2=CC=CC3=CC=CC=C32
Uses S-(+)-α-Naphthyl Glycidyl Ether is used in the preparation of Naftopidil (N213500) enantiomers.

Technology Process of Oxirane, ((1-naphthalenyloxy)methyl)-, (S)-

There total 3 articles about Oxirane, ((1-naphthalenyloxy)methyl)-, (S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2461-42-9
3-(1-naphthyloxy)-1,2-epoxypropane

: 62-53-3
aniline

: (R)-1-(naphthalen-1-yloxy)-3-(phenylamino)propan-2-ol

: C₁₉H₁₉NO₂

: 61249-00-1
(S)-(1-naphthyl) glycidyl ether

: 56715-28-7
(R)-1-(1-naphthyloxy)-2,3-epoxypropane

Guidance literature:: 3-(1-naphthyloxy)-1,2-epoxypropane; With C₆₅H₅₆CoN₃O₈; In dichloromethane; at 27 - 28 ℃; for 0.166667h;

aniline; In dichloromethane; at 27 - 28 ℃; enantioselective reaction;
DOI:10.1002/adsc.201700788

Reference yield:

: 2461-42-9
3-(1-naphthyloxy)-1,2-epoxypropane

: 36112-95-5
3-(1-naphthyloxy)propane-1,2-diol

: 61249-00-1
(S)-(1-naphthyl) glycidyl ether

Guidance literature:: With Bacillus megaterium ECU₁₀₀₁ epoxide hydrolase; In potassium phosphate buffer; dimethyl sulfoxide; at 30 ℃; for 2h; pH=7; optical yield given as %ee; enantioselective reaction; Resolution of racemate; Enzymatic reaction;
DOI:10.1002/adsc.201100031

Reference yield:

: 90-15-3
α-naphthol

: 36112-95-5
3-(1-naphthyloxy)propane-1,2-diol

: 61249-00-1
(S)-(1-naphthyl) glycidyl ether

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / water / 5 h / 20 °C

2: Bacillus megaterium ECU₁₀₀₁ epoxide hydrolase / potassium phosphate buffer; dimethyl sulfoxide / 2 h / 30 °C / pH 7 / Resolution of racemate; Enzymatic reaction

With Bacillus megaterium ECU₁₀₀₁ epoxide hydrolase; sodium hydroxide; In potassium phosphate buffer; water; dimethyl sulfoxide;
DOI:10.1002/adsc.201100031