1-(3-(4-(Bis(p-fluorophenyl)methyl)-1-piperazinyl)propyl)-6-phenyl-2-piperidinone ethanedioate

Base Information

Chemical Name:1-(3-(4-(Bis(p-fluorophenyl)methyl)-1-piperazinyl)propyl)-6-phenyl-2-piperidinone ethanedioate
CAS No.:109758-31-8
Molecular Formula:C33H37F2N3O5
Molecular Weight:593.6608
Hs Code.:
DSSTox Substance ID:DTXSID40911328
Mol file:109758-31-8.mol

Synonyms:109758-31-8;M.G. 16244;1-(3-(4-(Bis(p-fluorophenyl)methyl)-1-piperazinyl)propyl)-6-phenyl-2-piperidinone ethanedioate;2-Piperidinone, 1-(3-(4-(bis(p-fluorophenyl)methyl)-1-piperazinyl)propyl)-6-phenyl-, ethanedioate;1-[3-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]propyl]-6-phenyl-pip eridin-2-one, oxalic acid;1-[3-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]propyl]-6-phenylpiperidin-2-one;oxalic acid;DTXSID40911328;RWLDIUGGOKYKBT-UHFFFAOYSA-N;C31H35F2N3O.C2H2O4;LS-117221;1-[3-[4-[Bis(4-Fluorophenyl)Methyl]Piperazin-1-Yl]Propyl]-6-Phenylpiperidin-2-One oxalate;1-[3-[4-[BIS(4-FLUOROPHENYL)METHYL]PIPERAZIN-1-YL]PROPYL]-6-PHENYL-PIP ERIDIN-2-ONE,OXALIC ACID;Oxalic acid--1-(3-{4-[bis(4-fluorophenyl)methyl]piperazin-1-yl}propyl)-6-phenylpiperidin-2-one (1/1)

Suppliers and Price of 1-(3-(4-(Bis(p-fluorophenyl)methyl)-1-piperazinyl)propyl)-6-phenyl-2-piperidinone ethanedioate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(3-(4-(Bis(p-fluorophenyl)methyl)-1-piperazinyl)propyl)-6-phenyl-2-piperidinone ethanedioate

Chemical Property:

Vapor Pressure:5.22E-16mmHg at 25°C
Boiling Point:634.6°Cat760mmHg
Flash Point:337.6°C
PSA：101.39000
Density:g/cm³
LogP:4.78500
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:9
Exact Mass:593.27012761
Heavy Atom Count:43
Complexity:742

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC(N(C(=O)C1)CCCN2CCN(CC2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F)C5=CC=CC=C5.C(=O)(C(=O)O)O

Technology Process of 1-(3-(4-(Bis(p-fluorophenyl)methyl)-1-piperazinyl)propyl)-6-phenyl-2-piperidinone ethanedioate

There total 2 articles about 1-(3-(4-(Bis(p-fluorophenyl)methyl)-1-piperazinyl)propyl)-6-phenyl-2-piperidinone ethanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 41419-25-4
6-phenylpiperidin-2-one

: 109758-31-8
1-(3-{4-[Bis-(4-fluoro-phenyl)-methyl]-piperazin-1-yl}-propyl)-6-phenyl-piperidin-2-one; compound with oxalic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 26 percent / 80percent NaH / dimethylformamide / 3 h / Ambient temperature

2: 1.) KI, 2.) K₂CO₃ / 1.) isobutylmethylketone, reflux, 30 min, 2.) isobutylmethylketone, 48 h

With sodium hydride; potassium carbonate; potassium iodide; In N,N-dimethyl-formamide;

Reference yield:

: 144-62-7,97993-78-7
oxalic acid

: 27469-60-9
1-(4-fluorophenyl)methyl-piperazine

: 109758-07-8
1-(3-ciclopropil)-6-fenil-piperidin-2-one

: 109758-31-8
1-(3-{4-[Bis-(4-fluoro-phenyl)-methyl]-piperazin-1-yl}-propyl)-6-phenyl-piperidin-2-one; compound with oxalic acid

Guidance literature:: With potassium carbonate; potassium iodide; Yield given. Multistep reaction; 1.) isobutylmethylketone, reflux, 30 min, 2.) isobutylmethylketone, 48 h;