6-phenylpiperidin-2-one

Base Information

• Chemical Name: 6-phenylpiperidin-2-one
• CAS No.: 41419-25-4
• Molecular Formula: C11H13NO
• Molecular Weight: 175.23
• Mol file: 41419-25-4.mol

Synonyms:

Chemical Property of 6-phenylpiperidin-2-one

Chemical Property:

• Melting Point: 141-142℃ (benzene ligroine )
• Density: 1.073±0.06 g/cm3 (20 oC 760 Torr)
• Storage Temp.: 2-8°C

Purity/Quality:

NLT 98% ^*data from raw suppliers

6-Phenylpiperidin-2-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-phenylpiperidin-2-one

There total 28 articles about 6-phenylpiperidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

ethyl 5-phenyl-5-N-(2-pyridylsulfonylamino)pentanoate (1006713-41-2) → 6-phenylpiperidin-2-one (41419-25-4)

Guidance literature:

With magnesium; In methanol; at 20 ℃; for 2h;

DOI:10.1002/anie.200703239

Reference yield: 86.0%

6-phenyl-2-pyridone (19006-82-7) → 6-phenylpiperidin-2-one (41419-25-4)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 24h;

DOI:10.1002/ejoc.201801134

Reference yield: 85.0%

5-oxo-5-phenylvaleric acid (1501-05-9) → 6-phenylpiperidin-2-one (41419-25-4)

Guidance literature:

With water; formamide; at 160 ℃; for 4h; Autoclave; Green chemistry;

DOI:10.1002/cssc.201901780

upstream raw materials:

Methyl 4-benzoylbutanoate

formamide

5-hydroxyimino-5-phenylpentanoic acid methyl ester

S-(2-iodophenethyl) 5-azido-5-phenylpentanethioate

Downstream raw materials:

2-ethoxy-6-phenyl-3,4,5,6-tetrahydropyridine

6-Phenyl-1-(dichlor-fluor-methylsulfenyl)-2-piperidon

triethylamine hydrochloride

(2-bromo-4,5-dimethoxy-phenyl)-(5-phenyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridin-3-yl)-amine

Refernces

• 1、 -. "Method for synthesizing lactam derivative without catalyst". Paragraph 0046-0049. . Retrieved 2019/07/10.
• 2、 Mitsudo, Koichi,Yamamoto, Junya,Akagi, Tomoya,Yamashita, Atsuhiro,Haisa, Masahiro,Yoshioka, Kazuki,Mandai, Hiroki,Ueoka, Koji,Hempel, Christian,Yoshida, Jun-ichi,Suga, Seiji. "Stereoselective nucleophilic addition reactions to cyclic n-acyliminium ions using the indirect cation pool method: Elucidation of stereoselectivity by spectroscopic conformational analysis and dft calculations". supporting information. p. 1192 - 1202. Retrieved 2018/06/04.