2,2,2-trifluoro-N-(4-fluorophenyl)acetamide

Base Information

Chemical Name:2,2,2-trifluoro-N-(4-fluorophenyl)acetamide
CAS No.:35980-25-7
Molecular Formula:C8H5F4NO
Molecular Weight:207.127
Hs Code.:
NSC Number:322049
UNII:7M9C5AFJ8Z
DSSTox Substance ID:DTXSID30189539
Nikkaji Number:J3.584.400G
Wikidata:Q83061661
Mol file:35980-25-7.mol

Synonyms:2,2,2-trifluoro-N-(4-fluorophenyl)acetamide;35980-25-7;ACETANILIDE, 2,2,2,4'-TETRAFLUORO-;2,2,2,4'-Tetrafluoroacetanilide;NSC 322049;Acetamide, 2,2,2-trifluoro-N-(4-fluorophenyl)-;BRN 2725532;NSC-322049;Acetamide, N-(4-fluorophenyl)-2,2,2-trifluoro-;NSC322049;p-Fluorotrifluoroacetanilide;7M9C5AFJ8Z;SCHEMBL5549558;DTXSID30189539;AKOS002960474;BS-28463;J3.584.400G;N-(p-Fluorophenyl)-2,2,2-trifluoroacetamide;EN300-194552;Z111810696

Suppliers and Price of 2,2,2-trifluoro-N-(4-fluorophenyl)acetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2,2,2-trifluoro-N-(4-fluorophenyl)acetamide
50mg
$ 90.00

Chemcia Scientific
2,2,2-Trifluoro-N-(4-fluoro-phenyl)-acetamide 95%
2 G
$ 195.00

Total 3 raw suppliers

Chemical Property of 2,2,2-trifluoro-N-(4-fluorophenyl)acetamide

Chemical Property:

Vapor Pressure:0.036mmHg at 25°C
Boiling Point:241.4°C at 760 mmHg
Flash Point:99.8°C
PSA：29.10000
Density:1.447g/cm³
LogP:2.39950
XLogP3:2.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:1
Exact Mass:207.03072643
Heavy Atom Count:14
Complexity:208

Purity/Quality:: 2,2,2-trifluoro-N-(4-fluorophenyl)acetamide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC=C1NC(=O)C(F)(F)F)F

Technology Process of 2,2,2-trifluoro-N-(4-fluorophenyl)acetamide

There total 7 articles about 2,2,2-trifluoro-N-(4-fluorophenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 371-40-4
4-fluoroaniline

: 76-05-1
trifluoroacetic acid

: 35980-25-7
N-(4-fluorophenyl)-2,2,2-trifluoro-acetamide

Guidance literature:: With bis(trichloromethyl) carbonate; triethylamine; In dichloromethane; at 20 ℃; for 0.25h;
DOI:10.2174/157017811797249317

Reference yield: 89.0%

: 81290-20-2
(trifluoromethyl)trimethylsilane

: 1195-45-5
para-fluorophenyl isocyanate

: 35980-25-7
N-(4-fluorophenyl)-2,2,2-trifluoro-acetamide

Guidance literature:: With tetramethylammonium fluoride; In 1,2-dimethoxyethane; at -60 - 20 ℃;
DOI:10.1016/S0040-4039(01)01764-6

Reference yield: 81.0%

: C₂₀H₉F₇NOS₂⁽¹⁺⁾*BF₄^(1-)

: 35980-25-7
N-(4-fluorophenyl)-2,2,2-trifluoro-acetamide

Guidance literature:: With tetrakis(acetonitrile)copper(I)tetrafluoroborate; [4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine-N1,N1′]bis{3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-κN]phenyl-κC}iridium(III) hexafluorophosphate; cesium fluoride; In acetone; at 30 ℃; for 20h; Inert atmosphere; Irradiation;
DOI:10.1038/s41557-019-0353-3