2,4-Dimethoxy-7,8,9,10-tetrahydroazepino[2,1-b]quinazolin-12(6H)-one

Base Information

Chemical Name:2,4-Dimethoxy-7,8,9,10-tetrahydroazepino[2,1-b]quinazolin-12(6H)-one
CAS No.:850656-09-6
Molecular Formula:C₁₅H₁₈N₂O₃
Molecular Weight:274.32
Hs Code.:
ChEMBL ID:CHEMBL2235297
DSSTox Substance ID:DTXSID50468792
Wikidata:Q82296198
Mol file:850656-09-6.mol

Synonyms:850656-09-6;CHEMBL2235297;DTXSID50468792;2,4-Dimethoxy-7,8,9,10-tetrahydroazepino[2,1-b]quinazolin-12(6H)-one

Suppliers and Price of 2,4-Dimethoxy-7,8,9,10-tetrahydroazepino[2,1-b]quinazolin-12(6H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 1 raw suppliers

Chemical Property of 2,4-Dimethoxy-7,8,9,10-tetrahydroazepino[2,1-b]quinazolin-12(6H)-one

Chemical Property:

PSA：53.35000
LogP:2.14010
XLogP3:1.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:274.13174244
Heavy Atom Count:20
Complexity:410

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC2=C(C(=C1)OC)N=C3CCCCCN3C2=O

Technology Process of 2,4-Dimethoxy-7,8,9,10-tetrahydroazepino[2,1-b]quinazolin-12(6H)-one

There total 8 articles about 2,4-Dimethoxy-7,8,9,10-tetrahydroazepino[2,1-b]quinazolin-12(6H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.34%

: 67-56-1
methanol

: 122229-02-1
2,4-dibromo-7,8,9,10-tetrahydroazepino<2,1-b>quinazolin-12(6H)-one

: 850656-09-6
2,4-dimethoxy-6,7,8,9,10,12-hexahydroazepino[2,1-b]quinazolin-12-one

Guidance literature:: With sodium methylate; copper dichloride; for 12h; Inert atmosphere; Reflux;
DOI:10.1007/s00044-011-9641-1

Reference yield: 64.23%

: 124-41-4
sodium methylate

: 122229-02-1
2,4-dibromo-7,8,9,10-tetrahydroazepino<2,1-b>quinazolin-12(6H)-one

: 850656-09-6
2,4-dimethoxy-6,7,8,9,10,12-hexahydroazepino[2,1-b]quinazolin-12-one

Guidance literature:: With copper dichloride; In methanol; at 120 ℃; for 14h; under 4240.61 Torr;
DOI:10.1016/j.ejmech.2005.09.010

Reference yield:

: 118-92-3,159201-01-1,50816-84-7,80206-34-4,104809-47-4
anthranilic acid

: 850656-09-6
2,4-dimethoxy-6,7,8,9,10,12-hexahydroazepino[2,1-b]quinazolin-12-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: 59.66 percent / Br₂ / methanol / 3 h / 50 °C

2.1: SOCl₂ / benzene / 2 h / Heating

2.2: 73.65 percent / benzene / 12 h

3.1: 64.23 percent / CuCl₂ / methanol / 14 h / 120 °C / 4240.61 Torr

With thionyl chloride; bromine; copper dichloride; In methanol; benzene;
DOI:10.1016/j.ejmech.2005.09.010