Carbamic acid, [(1S)-2-[(1R)-3,4-dihydro-4-hydroxy-7,8-dimethoxy-6-methyl-1-[(phenyl methoxy)methyl]-5-(2-propenyloxy)-2(1H)-isoquinolinyl]-1-[[4-methoxy-2- [[(4-methoxyphenyl)methoxy]methyl]-5-methyl-3-(phenylmethoxy)phenyl] methyl]-2-oxoethyl]methyl-, 1,1-dimethylethyl ester

Base Information

Chemical Name:Carbamic acid, [(1S)-2-[(1R)-3,4-dihydro-4-hydroxy-7,8-dimethoxy-6-methyl-1-[(phenyl methoxy)methyl]-5-(2-propenyloxy)-2(1H)-isoquinolinyl]-1-[[4-methoxy-2- [[(4-methoxyphenyl)methoxy]methyl]-5-methyl-3-(phenylmethoxy)phenyl] methyl]-2-oxoethyl]methyl-, 1,1-dimethylethyl ester
CAS No.:851121-88-5
Molecular Formula:C56H68N2O12
Molecular Weight:961.162
Hs Code.:

Carbamic acid,
[(1S)-2-[(1R)-3,4-dihydro-4-hydroxy-7,8-dimethoxy-6-methyl-1-[(phenyl
methoxy)methyl]-5-(2-propenyloxy)-2(1H)-isoquinolinyl]-1-[[4-methoxy-2-
[[(4-methoxyphenyl)methoxy]methyl]-5-methyl-3-(phenylmethoxy)phenyl]
methyl]-2-oxoethyl]methyl-, 1,1-dimethylethyl ester

Synonyms:

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Chemical Property of Carbamic acid, [(1S)-2-[(1R)-3,4-dihydro-4-hydroxy-7,8-dimethoxy-6-methyl-1-[(phenyl methoxy)methyl]-5-(2-propenyloxy)-2(1H)-isoquinolinyl]-1-[[4-methoxy-2- [[(4-methoxyphenyl)methoxy]methyl]-5-methyl-3-(phenylmethoxy)phenyl] methyl]-2-oxoethyl]methyl-, 1,1-dimethylethyl ester

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Technology Process of Carbamic acid, [(1S)-2-[(1R)-3,4-dihydro-4-hydroxy-7,8-dimethoxy-6-methyl-1-[(phenyl methoxy)methyl]-5-(2-propenyloxy)-2(1H)-isoquinolinyl]-1-[[4-methoxy-2- [[(4-methoxyphenyl)methoxy]methyl]-5-methyl-3-(phenylmethoxy)phenyl] methyl]-2-oxoethyl]methyl-, 1,1-dimethylethyl ester

There total 23 articles about Carbamic acid, [(1S)-2-[(1R)-3,4-dihydro-4-hydroxy-7,8-dimethoxy-6-methyl-1-[(phenyl methoxy)methyl]-5-(2-propenyloxy)-2(1H)-isoquinolinyl]-1-[[4-methoxy-2- [[(4-methoxyphenyl)methoxy]methyl]-5-methyl-3-(phenylmethoxy)phenyl] methyl]-2-oxoethyl]methyl-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 851121-83-0
(R)-5-Allyloxy-1-benzyloxymethyl-7,8-dimethoxy-6-methyl-1,2,3,4-tetrahydro-isoquinolin-4-ol

: 351377-62-3
3-[3-benzyloxy-4-methoxy-2-(4-methoxy-benzyloxymethyl)-5-methyl-phenyl]-2-(tert-butoxycarbonyl-methyl-amino)-propionic acid

: 851121-88-5
{2-(5-allyloxy-1-benzyloxymethyl-4-hydroxy-7,8-dimethoxy-6-methyl-3,4-dihydro-1H-isoquinolin-2-yl)-1-[3-benzyloxy-4-methoxy-2-(4-methoxy-benzyloxymethyl)-5-methyl-benzyl]-2-oxo-ethyl}-methyl-carbamic acid tert-butyl ester

Guidance literature:: With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; In dichloromethane; at 20 ℃; for 72h;

Reference yield:

: 351379-10-7
2-hydroxymethyl-3-iodo-6-methoxy-5-methyl-phenol

: 851121-88-5
{2-(5-allyloxy-1-benzyloxymethyl-4-hydroxy-7,8-dimethoxy-6-methyl-3,4-dihydro-1H-isoquinolin-2-yl)-1-[3-benzyloxy-4-methoxy-2-(4-methoxy-benzyloxymethyl)-5-methyl-benzyl]-2-oxo-ethyl}-methyl-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: 85 percent / K₂CO₃ / acetone / 4 h / Heating

2.1: sodium hydride / tetrahydrofuran; dimethylformamide / 0.17 h / 0 °C

2.2: 99 percent / TBAI / tetrahydrofuran; dimethylformamide / 12 h / 20 °C

3.1: 87 percent / TEA; TBABr; (o-tolyl)3P / Pd(OAc)2 / acetonitrile / 12 h / 80 °C

4.1: 93 percent / H₂; Rh[(COD)-(S,S)-Et-DuPhos]⁽¹⁺⁾*TfO^(1-) / CH₂Cl₂; methanol / 72 h / 20 °C / 5171.48 Torr

5.1: 93 percent / aq. LiOH / methanol; tetrahydrofuran / 11 h / 20 °C

6.1: 82 percent / sodium hydride / tetrahydrofuran / 15 h / 20 °C

7.1: BOPCl; TEA / CH₂Cl₂ / 72 h / 20 °C

With lithium hydroxide; (+)-1,2-bis((2S,,5S)-2,5-diethylphospholano)benzene(cyclooctadiene)rhodium(I) trifluoromethanesulfonate; TEA; tetrabutylammomium bromide; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; sodium hydride; potassium carbonate; tris-(o-tolyl)phosphine; palladium diacetate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetone; acetonitrile; 3.1: Jeffery-Heck coupling;
DOI:10.1021/ja050203t

Reference yield:

: 351380-16-0
toluene-4-sulfonic acid 5-iodo-2-methoxy-3-methyl-phenyl ester

: 851121-88-5
{2-(5-allyloxy-1-benzyloxymethyl-4-hydroxy-7,8-dimethoxy-6-methyl-3,4-dihydro-1H-isoquinolin-2-yl)-1-[3-benzyloxy-4-methoxy-2-(4-methoxy-benzyloxymethyl)-5-methyl-benzyl]-2-oxo-ethyl}-methyl-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 9 steps

1.1: 90 percent / aq. NaOH / ethane-1,2-diol / 5 h / Heating

2.1: Et₂AlCl / CH₂Cl₂ / 1 h / 20 °C

2.2: 86 percent / CH₂Cl₂ / 24 h / 20 °C

3.1: 85 percent / K₂CO₃ / acetone / 4 h / Heating

4.1: sodium hydride / tetrahydrofuran; dimethylformamide / 0.17 h / 0 °C

4.2: 99 percent / TBAI / tetrahydrofuran; dimethylformamide / 12 h / 20 °C

5.1: 87 percent / TEA; TBABr; (o-tolyl)3P / Pd(OAc)2 / acetonitrile / 12 h / 80 °C

6.1: 93 percent / H₂; Rh[(COD)-(S,S)-Et-DuPhos]⁽¹⁺⁾*TfO^(1-) / CH₂Cl₂; methanol / 72 h / 20 °C / 5171.48 Torr

7.1: 93 percent / aq. LiOH / methanol; tetrahydrofuran / 11 h / 20 °C

8.1: 82 percent / sodium hydride / tetrahydrofuran / 15 h / 20 °C

9.1: BOPCl; TEA / CH₂Cl₂ / 72 h / 20 °C

With lithium hydroxide; sodium hydroxide; (+)-1,2-bis((2S,,5S)-2,5-diethylphospholano)benzene(cyclooctadiene)rhodium(I) trifluoromethanesulfonate; TEA; tetrabutylammomium bromide; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; diethylaluminium chloride; sodium hydride; potassium carbonate; tris-(o-tolyl)phosphine; palladium diacetate; In tetrahydrofuran; methanol; dichloromethane; ethylene glycol; N,N-dimethyl-formamide; acetone; acetonitrile; 5.1: Jeffery-Heck coupling;
DOI:10.1021/ja050203t