AURORA 477

Base Information

• Chemical Name: AURORA 477
• CAS No.: 7465-93-2
• Molecular Formula: C14H12ClNO2
• Molecular Weight: 261.708
• Hs Code.: 2924299090
• Mol file: 7465-93-2.mol

Synonyms:Benzamide,N-(3-chlorophenyl)-4-methoxy;3-chloro-1-(p-methoxybenzoylamino)benzene;F3095-4503;N-(p-methoxybenzoyl)-m-chloroaniline;4-Methoxy-benzoesaeure-<3-chlor-anilid>;

Chemical Property of AURORA 477

Chemical Property:

• Vapor Pressure: 0.000203mmHg at 25°C
• Boiling Point: 327.4°C at 760 mmHg
• Flash Point: 151.8°C
• PSA: 38.33000
• Density: 1.281g/cm³
• LogP: 3.67390

Purity/Quality:

99% ^*data from raw suppliers

N-(3-CHLOROPHENYL)-4-METHOXYBENZAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of AURORA 477

There total 6 articles about AURORA 477 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.8%

4-methoxy-benzoyl chloride (100-07-2) + 3-chloro-aniline (108-42-9) → N-(3-chlorophenyl)-4-methoxybenzamide (7465-93-2)

Guidance literature:

With pyridine; for 2h; Reflux;

DOI:10.1016/j.jmgm.2010.04.003

Reference yield: 50.0%

4-methoxyphenylacetamide (3424-93-9) + 3-iodochlorobenzene (625-99-0) → N-(3-chlorophenyl)-4-methoxybenzamide (7465-93-2)

Guidance literature:

With copper(I) oxide; potassium phosphate; tetra-n-propylammonium bromide; In water; at 130 ℃; for 24h;

DOI:10.1016/j.tetlet.2011.01.003

Reference yield: 12.0%

N1-benzoyl-N1,N2-diphenylacetamidine (3460-08-0) + 4-methoxybenzoic acid (100-09-4) + 3-chloro-aniline (108-42-9) → N-phenyl benzoyl amide (93-98-1,5705-51-1) + 3'-chloro-benzanilide (6004-21-3) + N-(3-chlorophenyl)-4-methoxybenzamide (7465-93-2) + (E)-N,N'-diphenylacetimidamide (621-09-0,141417-91-6,1086215-03-3,1452517-10-0) + Acetanilid (103-84-4) + 4-methoxy-N-phenylbenzamide (7465-88-5)

Guidance literature:

In 1,4-dioxane; for 2h; Ambient temperature;

DOI:10.1248/cpb.38.1176

upstream raw materials:

4-methoxy-benzoyl chloride

3-chloro-aniline

N¹-benzoyl-N¹,N²-diphenylacetamidine

4-methoxybenzoic acid

Downstream raw materials:

C₁₄H₁₀ClNOS

5-chloro-2-(4-methoxyphenyl)-1,3-benzothiazole

N-(3-chlorophenyl)-4-methoxybenzenecarbothioamide

(3-Chloro-phenyl)-(4-methoxy-benzoyl)-carbamic acid isopropyl ester

Refernces

• 1、 Bhuva, Hemal A.,Kini, Suvarna G.. "Synthesis, anticancer activity and docking of some substituted benzothiazoles as tyrosine kinase inhibitors". experimental part. p. 32 - 37. Retrieved 2011/10/09.
• 2、 Ono,Hayakawa,Tamura. "Amidines. IV. Hydrolysis of N1-acyl derivatives of N1,N2-diarylamidine in carboxylate buffer solution". . p. 1176 - 1181. Retrieved 2007/10/02.