(1-Methyl-1H-imidazol-2-yl)methanol

Base Information

• Chemical Name: (1-Methyl-1H-imidazol-2-yl)methanol
• CAS No.: 17334-08-6
• Molecular Formula: C5H8N2O
• Molecular Weight: 112.131
• Hs Code.: 2933290090
• Mol file: 17334-08-6.mol

Synonyms:Imidazole-2-methanol,1-methyl- (6CI,8CI);(1-Methyl-1H-imidazole-2-yl)methanol;(1-Methylimidazol-2-yl)methanol;1-Methyl-1H-imidazol-2-ylmethanol;1-Methyl-1H-imidazole-2-methanol;1-Methyl-2-(hydroxymethyl)imidazole;1-Methylimidazole-2-methanol;2-Hydroxymethyl-1-methyl-1H-imidazole;2-Hydroxymethyl-1-methylimidazole;N-Methyl-2-hydroxymethylimidazole;(1-methyl-1H-imidazol-2-yl)methanol;1H-Imidazole-2-methanol, 1-methyl-;Imidazole-2-methanol, 1-methyl-;

Chemical Property of (1-Methyl-1H-imidazol-2-yl)methanol

Chemical Property:

• Appearance/Colour: white solid
• Vapor Pressure: 0.00187mmHg at 25°C
• Melting Point: 116-119°C
• Refractive Index: 1.552
• Boiling Point: 279.9 °C at 760 mmHg
• PKA: 13.41±0.10(Predicted)
• Flash Point: 123.1 °C
• PSA: 38.05000
• Density: 1.16 g/cm³
• LogP: -0.08760
• Storage Temp.: Inert atmosphere,Room Temperature
• Water Solubility.: Slightly soluble in water.

Purity/Quality:

98%,99%, ^*data from raw suppliers

(1-Methyl-1H-imidazol-2-yl)methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39-37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-Methyl-2-imidazolemethanol is used as intermediates.

Technology Process of (1-Methyl-1H-imidazol-2-yl)methanol

There total 8 articles about (1-Methyl-1H-imidazol-2-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

→ 1-methyl-2-hydroxymethylimidazole (17334-08-6)

Guidance literature:

With bis(1,5-cyclooctadiene)diiridium(I) dichloride; ethanol; hydrogen; C₃₁H₃₀FeNOP; isopropyl alcohol; lithium tert-butoxide; at 20 ℃; for 12h; under 750.075 Torr;

Reference yield: 92.0%

1-methyl-1H-imidazole (616-47-7) + formaldehyd (50-00-0,30525-89-4,61233-19-0) → 1-methyl-2-hydroxymethylimidazole (17334-08-6)

Guidance literature:

In acetonitrile; at 119.84 ℃; for 16h; High pressure; Inert atmosphere;

DOI:10.1080/00958972.2014.940335

Reference yield: 90.0%

N-methyl-2-imidazolcarboxaldehyde (13750-81-7) → 1-methyl-2-hydroxymethylimidazole (17334-08-6)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 1h;

DOI:10.1016/S0040-4020(99)01031-5

upstream raw materials:

1-methyl-1H-imidazole

formaldehyd

ethyl 1-methyl-1H-imidazole-2-carboxylate

2-chloromethyl-1-methylimidazole

Downstream raw materials:

2-chloromethyl-1-methyl-imidazol hydrochloride

N-methyl-2-imidazolcarboxaldehyde

1-methyl-2-[(N-methylaminocarbamoyloxy)methyl]imidazole

1-tert-butoxycarbonyl-4-[2-((1-methyl-1H-imidazol-2-yl)methoxy)phenyl]piperazine

Refernces

• 1、 Jones, Simon,Northen, Julian,Rolfe, Alan. "Catalytic phosphorylation using a bifunctional imidazole derived nucleophilic catalyst". . p. 3832 - 3834. Retrieved 2005.
• 2、 Zhou, Ying-Hua,Sun, Da-Liang,Tao, Jun,Chen, Li-Qing,Huang, Ya-Fan,Li, Ying-Kun,Cheng, Yong. "Synthesis, crystal structure, and SOD-like activity of two copper(II) complexes with hydroxymethyl pendants". . p. 2393 - 2404. Retrieved 2014.
• 3、 Vanelle,Maldonado,Crozet,Savornin,Delmas,Gasquet,Timon-David. "Synthesis and leishmanicidal activity of new 1-methyl-2-alkoxymethylimidazoles". . p. 551 - 553. Retrieved 1992.
• 4、 -. "PNO ligand containing planar chiral ferrocene and application thereof". Paragraph 0114-0118. . Retrieved 2021/06/21.