H-PHE-PHE-PHE-OH

Base Information

• Chemical Name: H-PHE-PHE-PHE-OH
• CAS No.: 2578-81-6
• Molecular Formula: C27H29 N3 O4
• Molecular Weight: 459.545
• Mol file: 2578-81-6.mol

Synonyms:Alanine,3-phenyl-N-[3-phenyl-N-(3-phenyl-L-alanyl)-L-alanyl]- (7CI,8CI);L-Phenylalanine, N-(N-L-phenylalanyl-L-phenylalanyl)-; L-Phe-L-Phe-L-Phe;L-Phenylalanyl-L-phenylalanyl-L-phenylalanine; Tri(phenylalanine)

Chemical Property of H-PHE-PHE-PHE-OH

Chemical Property:

• Vapor Pressure: 3.18E-26mmHg at 25°C
• Boiling Point: 788.8°C at 760 mmHg
• PKA: 3.49±0.10(Predicted)
• Flash Point: 430.9°C
• PSA: 121.52000
• Density: 1.24g/cm³
• LogP: 3.57810
• Storage Temp.: -15°C

Purity/Quality:

98%min ^*data from raw suppliers

PHE-PHE-PHE-OH 98.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: H-Phe-Phe-Phe-OH, can be used in peptide chemistry.

Technology Process of H-PHE-PHE-PHE-OH

There total 10 articles about H-PHE-PHE-PHE-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

N-Fmoc L-Phe (35661-40-6) → triphenylalanine (2578-81-6)

Guidance literature:

N-Fmoc L-Phe; With N-ethyl-N,N-diisopropylamine; In dichloromethane;

With piperidine; In 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide; for 0.25h;

N-Fmoc L-Phe; Further stages;

DOI:10.1007/s12195-017-0478-7

Reference yield:

methyl (2S)-2-amino-3-phenylpropanoate (2577-90-4) → Phe-Phe (2577-40-4) + triphenylalanine (2578-81-6) + L-phenylalanyl-L-phenyalanyl-L-phenylalnine methyl ester (17528-17-5) + (3S,6S)-3,6-dibenzylpiperazine-2,5-dione (2862-51-3)

Guidance literature:

With aminolysin-S; In dimethyl sulfoxide; at 50 ℃; for 23h; pH=7.5; aq. phosphate buffer; Enzymatic reaction;

DOI:10.1039/b914320c

Reference yield:

H-Phe-OEt (3081-24-1) → (L-F)3-OEt (103676-11-5) + Phe-Phe (2577-40-4) + triphenylalanine (2578-81-6) + (3S,6S)-3,6-dibenzylpiperazine-2,5-dione (2862-51-3)

Guidance literature:

With aminolysin-S; In dimethyl sulfoxide; at 50 ℃; for 23h; pH=7.5; aq. phosphate buffer; Enzymatic reaction;

DOI:10.1039/b914320c

upstream raw materials:

L-phenylalanine

methyl (2S)-2-amino-3-phenylpropanoate

H-Phe-OEt

L-Phenylalanine amide

Downstream raw materials:

L-phenylalanine

Refernces

• 1、 Her, Sohyoung,Kluger, Ronald. "Biomimetic protecting-group-free 2′, 3′-selective aminoacylation of nucleosides and nucleotides". supporting information; experimental part. p. 676 - 678. Retrieved 2011/03/22.
• 2、 Dhiman, Raj S.,Opinska, Liliana Guevara,Kluger, Ronald. "Biomimetic peptide bond formation in water with aminoacyl phosphate esters". supporting information; experimental part. p. 5645 - 5647. Retrieved 2011/09/15.