(S)-ethyl 1-(1-((tert-butyldimethylsilyl)oxy)-3-methylbutan-2-yl)-7-fluoro-6-iodo-4-oxo-1,4-dihydroquinoline-3-carboxylate

Base Information

Chemical Name:(S)-ethyl 1-(1-((tert-butyldimethylsilyl)oxy)-3-methylbutan-2-yl)-7-fluoro-6-iodo-4-oxo-1,4-dihydroquinoline-3-carboxylate
CAS No.:870294-02-3
Molecular Formula:C23H33FINO4Si
Molecular Weight:561.508
Hs Code.:
Mol file:870294-02-3.mol

Synonyms:

Suppliers and Price of (S)-ethyl 1-(1-((tert-butyldimethylsilyl)oxy)-3-methylbutan-2-yl)-7-fluoro-6-iodo-4-oxo-1,4-dihydroquinoline-3-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 8 raw suppliers

Chemical Property of (S)-ethyl 1-(1-((tert-butyldimethylsilyl)oxy)-3-methylbutan-2-yl)-7-fluoro-6-iodo-4-oxo-1,4-dihydroquinoline-3-carboxylate

Chemical Property:

PSA：57.53000
LogP:6.14080

Purity/Quality:: 99%, ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (S)-ethyl 1-(1-((tert-butyldimethylsilyl)oxy)-3-methylbutan-2-yl)-7-fluoro-6-iodo-4-oxo-1,4-dihydroquinoline-3-carboxylate

There total 9 articles about (S)-ethyl 1-(1-((tert-butyldimethylsilyl)oxy)-3-methylbutan-2-yl)-7-fluoro-6-iodo-4-oxo-1,4-dihydroquinoline-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 697762-60-0
7-fluoro-1-(1(S)-hydroxymethyl-2-methylprop-1-yl)-6-iodo-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester

: 18162-48-6
tert-butyldimethylsilyl chloride

: 870294-02-3
1-((2S)-1-tert-butyldimethylsilyloxy-3-methylbutan-2-yl)-7-fluoro-6-iodo-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester

Guidance literature:: With 1H-imidazole; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 1.5h; Product distribution / selectivity;

Reference yield:

: 697762-39-3
ethyl 2-(2,4-difluoro-5-iodobenzoyl)-3-(dimethylamino)acrylate

: 870294-02-3
1-((2S)-1-tert-butyldimethylsilyloxy-3-methylbutan-2-yl)-7-fluoro-6-iodo-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran

2: K₂CO₃ / dimethylformamide / 70 °C

3: imidazole / dimethylformamide

With 1H-imidazole; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm0600139

Reference yield:

: 2026-48-4,473-75-6
(S)-valinol

: 870294-02-3
1-((2S)-1-tert-butyldimethylsilyloxy-3-methylbutan-2-yl)-7-fluoro-6-iodo-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran

2: K₂CO₃ / dimethylformamide / 70 °C

3: imidazole / dimethylformamide

With 1H-imidazole; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm0600139