4-(t-Butyldimethylsilyloxy)-2,3-difluorophenylboronic acid

Base Information

Chemical Name:4-(t-Butyldimethylsilyloxy)-2,3-difluorophenylboronic acid
CAS No.:870646-83-6
Molecular Formula:C12H19BF2O3Si
Molecular Weight:288.17100
Hs Code.:2931900090
Mol file:870646-83-6.mol

Synonyms:I04-2001;A-3016;4-tert-butyldimethylsilyloxy-2,3-difluorophenylboronic acid;4-(t-Butyldimethylsilyloxy)-2,3-difluorophenylboronic acid;

Suppliers and Price of 4-(t-Butyldimethylsilyloxy)-2,3-difluorophenylboronic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-(t-Butyldimethylsilyloxy)-2,3-difluorophenylboronicacid
250mg
$ 75.00

Crysdot
4-(t-Butyldimethylsilyloxy)-2,3-difluorophenylboronicacid 95+%
10g
$ 564.00

Crysdot
4-(t-Butyldimethylsilyloxy)-2,3-difluorophenylboronicacid 95+%
5g
$ 339.00

Apolloscientific
4-(tert-Butyldimethylsilyloxy)-2,3-difluorophenylboronicacid 98%
1g
$ 131.00

AK Scientific
4-(t-Butyldimethylsilyloxy)-2,3-difluorophenylboronicacid
10g
$ 851.00

Total 7 raw suppliers

Chemical Property of 4-(t-Butyldimethylsilyloxy)-2,3-difluorophenylboronic acid

Chemical Property:

PSA：49.69000
LogP:2.02860

Purity/Quality:

97% ^*data from raw suppliers

4-(t-Butyldimethylsilyloxy)-2,3-difluorophenylboronicacid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4-(t-Butyldimethylsilyloxy)-2,3-difluorophenylboronic acid

There total 6 articles about 4-(t-Butyldimethylsilyloxy)-2,3-difluorophenylboronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 870646-82-5
2,3-difluoro-(tert-butyldimethylsilyloxy)benzene

: 121-43-7,63156-11-6
Trimethyl borate

: 7732-18-5
water

: 870646-83-6
4-tert-butyldimethylsilyloxy-2,3-difluorophenylboronic acid

Guidance literature:: 2,3-difluoro-(tert-butyldimethylsilyloxy)benzene; With n-butyllithium; In tetrahydrofuran; hexane; at -70 ℃; for 0.75h; Inert atmosphere;

Trimethyl borate; In tetrahydrofuran; hexane; at -70 ℃; for 0.5h; Inert atmosphere;

water; With hydrogenchloride; pH=6;

Reference yield:

: C₁₄H₂₃BF₂O₃Si

: 870646-83-6
4-tert-butyldimethylsilyloxy-2,3-difluorophenylboronic acid

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; at 20 ℃; for 1h;
DOI:10.1021/ja0549594

Reference yield:

: 870646-82-5
2,3-difluoro-(tert-butyldimethylsilyloxy)benzene

: 870646-83-6
4-tert-butyldimethylsilyloxy-2,3-difluorophenylboronic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran / 2.5 h / -78 °C

1.2: tetrahydrofuran / -78 - 20 °C

2.1: 8.18 g / aq. HCl / tetrahydrofuran / 1 h / 20 °C

With hydrogenchloride; n-butyllithium; In tetrahydrofuran;
DOI:10.1021/ja0549594