N-Methoxy-N,2-dimethyl-oxazole-4-carboxamide

Base Information

• Chemical Name: N-Methoxy-N,2-dimethyl-oxazole-4-carboxamide
• CAS No.: 875553-59-6
• Molecular Formula: C7H10N2O3
• Molecular Weight: 170.168
• Hs Code.: 2934999090
• Mol file: 875553-59-6.mol

Synonyms:N-METHOXY-N-METHYL-2-METHYLOXAZOLE-4-CARBOXAMIDE;2-methyloxazole-4-carboxylic acid N-methoxy-N-methylamide;

Chemical Property of N-Methoxy-N,2-dimethyl-oxazole-4-carboxamide

Chemical Property:

• Vapor Pressure: 0.00124mmHg at 25°C
• Boiling Point: 298.8oC at 760 mmHg
• Flash Point: 134.5oC
• PSA: 55.57000
• Density: 1.186g/cm3
• LogP: 0.61640

Purity/Quality:

96% ^*data from raw suppliers

N-Methoxy-N,2-dimethyl-oxazole-4-carboxamide Aldrich ^*data from reagent suppliers

Safty Information:

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-Methoxy-N,2-dimethyl-oxazole-4-carboxamide

There total 3 articles about N-Methoxy-N,2-dimethyl-oxazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

→ N-methoxy-N-methyl-2-methyloxazole-4-carboxamide (875553-59-6)

Guidance literature:

Reference yield: 89.58%

2-methyl-1,3-oxazol-4-carboxylic acid (23012-17-1) + N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) → N-methoxy-N-methyl-2-methyloxazole-4-carboxamide (875553-59-6)

Guidance literature:

2-methyl-1,3-oxazol-4-carboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 0 ℃; for 0.5h;

N,O-dimethylhydroxylamine*hydrochloride; In dichloromethane; at 20 ℃; for 18h;

Reference yield:

2-methyl-4-carbethoxy-1,3-oxazole (10200-43-8) → N-methoxy-N-methyl-2-methyloxazole-4-carboxamide (875553-59-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: water; sodium hydroxide / 1 h / 20 - 25 °C / Large scale

2.1: triethylamine / dichloromethane; water / 1 h / 20 °C / Large scale

2.2: 1 h / 0 - 20 °C / Large scale

With water; triethylamine; sodium hydroxide; In dichloromethane; water;

DOI:10.1021/op700198s

upstream raw materials:

2-methyl-4-carbethoxy-1,3-oxazole

2-methyl-1,3-oxazol-4-carboxylic acid

N,O-dimethylhydroxylamine*hydrochloride

Downstream raw materials:

2-methyl-1,3-oxazole-4-carbaldehyde

4-hydroxymethyl-2-methyloxazole

{5-({[tert-butyl(diphenyl)silyl]oxy}methyl)-4-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-2,3-difluorophenyl}(2-methyl-1,3-oxazol-4-yl)methanone

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