1H-Pyrrole-2,5-dicarboxylic acid, 3-[4-methoxy-3-(1-methylethoxy)phenyl]-1-[2-[4-methoxy-3-(1-methyleth oxy)phenyl]ethyl]-4-[[(trifluoromethyl)sulfonyl]oxy]-, dimethyl ester

Base Information

Chemical Name:1H-Pyrrole-2,5-dicarboxylic acid, 3-[4-methoxy-3-(1-methylethoxy)phenyl]-1-[2-[4-methoxy-3-(1-methyleth oxy)phenyl]ethyl]-4-[[(trifluoromethyl)sulfonyl]oxy]-, dimethyl ester
CAS No.:875654-40-3
Molecular Formula:C31H36F3NO11S
Molecular Weight:687.688
Hs Code.:

1H-Pyrrole-2,5-dicarboxylic acid,
3-[4-methoxy-3-(1-methylethoxy)phenyl]-1-[2-[4-methoxy-3-(1-methyleth
oxy)phenyl]ethyl]-4-[[(trifluoromethyl)sulfonyl]oxy]-, dimethyl ester

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Chemical Property of 1H-Pyrrole-2,5-dicarboxylic acid, 3-[4-methoxy-3-(1-methylethoxy)phenyl]-1-[2-[4-methoxy-3-(1-methyleth oxy)phenyl]ethyl]-4-[[(trifluoromethyl)sulfonyl]oxy]-, dimethyl ester

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Technology Process of 1H-Pyrrole-2,5-dicarboxylic acid, 3-[4-methoxy-3-(1-methylethoxy)phenyl]-1-[2-[4-methoxy-3-(1-methyleth oxy)phenyl]ethyl]-4-[[(trifluoromethyl)sulfonyl]oxy]-, dimethyl ester

There total 12 articles about 1H-Pyrrole-2,5-dicarboxylic acid, 3-[4-methoxy-3-(1-methylethoxy)phenyl]-1-[2-[4-methoxy-3-(1-methyleth oxy)phenyl]ethyl]-4-[[(trifluoromethyl)sulfonyl]oxy]-, dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 875654-32-3
dimethyl 1-[2-(3-isopropoxy-4-methoxyphenyl)ethyl]-3,4-bis(trifluoromethanesulfonyloxy)pyrrole-2,5-dicarboxylate

: 516465-82-0
(3-isopropoxy-4-methoxyphenyl)boronic acid

: 875654-40-3
dimethyl 3-(3-isopropoxy-4-methoxyphenyl)-1-[2-(3-isopropoxy-4-methoxyphenyl)ethyl]-4-(trifluoromethanesulfonyloxy)pyrrole-2,5-dicarboxylate

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; water; for 4h; Heating;
DOI:10.1016/j.tet.2005.10.014

Reference yield:

: 37942-01-1
5-bromo-2-methoxyphenol

: 875654-40-3
dimethyl 3-(3-isopropoxy-4-methoxyphenyl)-1-[2-(3-isopropoxy-4-methoxyphenyl)ethyl]-4-(trifluoromethanesulfonyloxy)pyrrole-2,5-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 96 percent / potassium carbonate / dimethylsulfoxide / 2 h / 55 °C

2.1: tert-butyllithium / tetrahydrofuran; pentane / 1 h / -78 °C

2.2: 81 percent / trimethyl borate / tetrahydrofuran; pentane / -78 - 20 °C

3.1: 77 percent / sodium carbonate / Pd(PPh₃)4 / tetrahydrofuran; H₂O / 4 h / Heating

With tert.-butyl lithium; sodium carbonate; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; water; dimethyl sulfoxide; pentane; 3.1: Suzuki-Miyaura coupling;
DOI:10.1016/j.tet.2005.10.014

Reference yield:

: 871571-19-6
5-bromo-2-methoxyphenyl methanesulfonate

: 875654-40-3
dimethyl 3-(3-isopropoxy-4-methoxyphenyl)-1-[2-(3-isopropoxy-4-methoxyphenyl)ethyl]-4-(trifluoromethanesulfonyloxy)pyrrole-2,5-dicarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 91 percent / LDA / heptane; tetrahydrofuran; ethylbenzene / 0.08 h / 0 °C

2.1: 96 percent / potassium carbonate / dimethylsulfoxide / 2 h / 55 °C

3.1: tert-butyllithium / tetrahydrofuran; pentane / 1 h / -78 °C

3.2: 81 percent / trimethyl borate / tetrahydrofuran; pentane / -78 - 20 °C

4.1: 77 percent / sodium carbonate / Pd(PPh₃)4 / tetrahydrofuran; H₂O / 4 h / Heating

With tert.-butyl lithium; sodium carbonate; potassium carbonate; lithium diisopropyl amide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; n-heptane; ethylbenzene; water; dimethyl sulfoxide; pentane; 4.1: Suzuki-Miyaura coupling;
DOI:10.1016/j.tet.2005.10.014