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| CAS No.: | 15826-37-6 |
|---|---|
| Name: | Sodium cromoglycate |
| Article Data: | 25 |
| Molecular Structure: | |
|
|
|
| Formula: | C23H14Na2O11 |
| Molecular Weight: | 512.337 |
| Synonyms: | Aarane;Allergocrom;Altoderm;Colimune;Cromolyn disodium salt;Cromovet;DSCG;Disodium 1,3-bis(2-carboxy-5-chromonyloxy)-2-propanol;Disodium chromoglycate; |
| EINECS: | 239-926-7 |
| Melting Point: | 241-242 °C |
| Boiling Point: | 752.3 °C at 760 mmHg |
| Flash Point: | 263.9 °C |
| Solubility: | Soluble in water to 100mg/ml |
| Appearance: | white crystalline powder |
| Hazard Symbols: |
 Xi
|
| Risk Codes: | 36/37/38 |
| Safety: | 26-36 |
| PSA: | 179.37000 |
| LogP: | -0.55490 |
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- 16150-45-1
1,3-bis(2-carboethoxychromon-5-yloxy)-2-hydroxypropane
- 15826-37-6
disodium cromoglicate
| Conditions | Yield |
|---|---|
| With sodium hydroxide In ethanol; water at 65℃; for 5h; Temperature; | 97.1% |
| Conditions | Yield |
|---|---|
| With azobisisobutyronitrile; nitrogen | |
| With azobisisobutyronitrile; nitrogen | |
| With azobisisobutyronitrile; nitrogen |
- 699-83-2
2,6-dihydroxylacetophenone
- 15826-37-6
disodium cromoglicate
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: sodium ethanolate / ethanol / 10 h / 60 °C 2: isopropyl alcohol / 10 h / 100 °C 3: sodium hydroxide / ethanol; water / 5 h / 65 °C View Scheme | |
| Multi-step reaction with 3 steps 1: sodium ethanolate / ethanol / 10 h / 60 °C 2: isopropyl alcohol / 6 h / 75 °C 3: sodium hydroxide / ethanol; water / 5 h / 65 °C View Scheme |
- 50521-64-7
5-hydroxy-4-oxo-4H-benzopyran-2-carboxylic acid ethyl ester
- 15826-37-6
disodium cromoglicate
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: isopropyl alcohol / 10 h / 100 °C 2: sodium hydroxide / ethanol; water / 5 h / 65 °C View Scheme |
- 64-17-5
ethanol
- 15826-37-6
disodium cromoglicate
- 16150-45-1
1,3-bis(2-carboethoxychromon-5-yloxy)-2-hydroxypropane
| Conditions | Yield |
|---|---|
| With hydrogenchloride at 95 - 100℃; for 28h; Inert atmosphere; | 80% |
| With hydrogenchloride In water at 100℃; for 24h; Sealed tube; | 76% |
| With hydrogenchloride In water at 100℃; for 24h; Sealed tube; | 76% |
- 15826-37-6
disodium cromoglicate
| Conditions | Yield |
|---|---|
| With rhodium(III) chloride; water-d2 In N,N-dimethyl-formamide at 108℃; | 77% |
- 15826-37-6
disodium cromoglicate
- 16110-51-3
cromoglicinic acid
| Conditions | Yield |
|---|---|
| With hydrogenchloride In water pH=3; | 66% |
| With hydrogenchloride In water pH=3; | 66% |
| With hydrogenchloride In water at 20℃; pH=2; |
- 15826-37-6
disodium cromoglicate
- 16150-44-0
(1-{2-[3-(2-acetyl-3-hydroxy-phenoxy)-2-hydroxypropoxy]-6-hydroxy-phenyl}-ethanone)
| Conditions | Yield |
|---|---|
| With sodium hydroxide for 0.333333h; Heating; | 59.7% |
| With potassium hydroxide In water for 2h; Reflux; |
- 15826-37-6
disodium cromoglicate
- 92588-95-9
C23H12(3)H2O11(2-)*2Na(1+)
| Conditions | Yield |
|---|---|
| With rhodium(III) chloride; tritium oxide In N,N-dimethyl-formamide at 108℃; |
- 15826-37-6
disodium cromoglicate
- 75-03-6
ethyl iodide
- 16150-45-1
1,3-bis(2-carboethoxychromon-5-yloxy)-2-hydroxypropane
| Conditions | Yield |
|---|---|
| In N,N-dimethyl-formamide 1.) 64-70 deg C, 5 h, 2.) 4-6 deg C, overnight; | 136 g |
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Chemistry
IUPAC Name: Disodium 5-[3-(2-carboxylato-4-oxochromen-5-yl)oxy-2-hydroxypropoxy]-4-oxochromene-2-carboxylate
Product Categories: Drug bulk;Intermediates & Fine Chemicals;Pharmaceuticals
Molecular Formula: C23H14O11·2 Na
Molecular Weight: 512.35
EINECS: 239-926-7
Melting Point: 241-2420 °C
Boiling Point: 752.3 °C at 760 mmHg
Flash Point: 263.9 °C
Enthalpy of Vaporization: 115.04 kJ/mol
Vapour Pressure: 8.92E-24 mmHg at 25°C
Appearance: White Crystalline Powder
Cromoglycate disodium's (15826-37-6) Synonyms: DSCG ; DISODIUM CROMOGLYCATE ; Disodium 5,5'-[(2-hydroxytrimethylene)dioxy]bis[4-oxo-4h-1-benzopyran-2-carboxylate] ; Disodium 1,3-bis(2-carboxy-5-chromonyloxy)-2-propanol ; CROMOGLYCATE SODIUM SALT ; CROMOGLYCIC ACID SODIUM SALT ; CROMOLYN SODIUM ; CROMOLYN SODIUM SALT
Cromoglycate disodium's (15826-37-6) Molecular Structure: 
Uses
Chromone complex which blocks mast cell degranulation.
Toxicity Data With Reference
| 1. | orl-wmn TDLo:96 mg/kg/6D-I:SKN | BMJOAE British Medical Journal. 289 (1984),470. | ||
| 2. | orl-hmn TDLo:34 mg/kg/4W:PUL | BMJOAE British Medical Journal. 2 (1976),916. | ||
| 3. | scu-rat LD50:6 g/kg | NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),244. | ||
| 4. | ipr-mus LD50:4100 mg/kg | NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),244. | ||
| 5. | scu-mus LD50:4400 mg/kg | NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),244. | ||
| 6. | ivn-mus LD50:3300 mg/kg | NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),244. | ||
| 7. | ivn-rbt LD50:2 g/kg | KSRNAM Kiso to Rinsho. Clinical Report. 4 (1970),189. |
Safety Profile
Moderately toxic by intravenous route. Mildly toxic by subcutaneous and intraperitoneal routes. Human systemic effects by ingestion: allergic dermatitis, respiratory depression and other lung effects. When heated to decomposition it emits toxic fumes of Na2O.
Safety Information of Cromoglycate disodium(15826-37-6)
Hazard Codes: Xi 
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
RIDADR: 3249
WGK Germany: 2
RTECS: DJ2380000
HazardClass: 6.1(b)
PackingGroup: III