2-[4-(methylsulfinyl)phenyl]-3-(pyridin-4-yl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazole

Base Information

• Chemical Name: 2-[4-(methylsulfinyl)phenyl]-3-(pyridin-4-yl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazole
• CAS No.: 122454-69-7
• Molecular Formula: C18H17 N3 O S
• Molecular Weight: 323.418
• Mol file: 122454-69-7.mol

Synonyms:SKF 105809

Chemical Property of 2-[4-(methylsulfinyl)phenyl]-3-(pyridin-4-yl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazole

Chemical Property:

• Vapor Pressure: 2.52E-12mmHg at 25°C
• Boiling Point: 567.9°Cat760mmHg
• Flash Point: 297.2°C
• Density: 1.36g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-[4-(methylsulfinyl)phenyl]-3-(pyridin-4-yl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazole

There total 8 articles about 2-[4-(methylsulfinyl)phenyl]-3-(pyridin-4-yl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

2-(4-methylthiophenyl)-3-(4-pyridyl)-6,7-dihydro-[5H]-pyrrolo-[1,2-a]-imidazole (122454-68-6) → SKF 105809 (122454-69-7)

Guidance literature:

With hydrogenchloride; sodium periodate; at 5 ℃; for 18h;

DOI:10.1016/S0968-0896(96)00212-X

Reference yield:

pyridine (110-86-1) → SKF 105809 (122454-69-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 75 percent / CH₂Cl₂ / Ambient temperature

2: 56 percent / t-BuOK, t-BuOH, O₂ / 19 h / Heating

3: 73 percent / dimethylformamide / 18 h / 80 °C

4: 60 percent / aq. HCl, NaIO₄ / 18 h / 5 °C

With hydrogenchloride; sodium periodate; potassium tert-butylate; oxygen; tert-butyl alcohol; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0968-0896(96)00212-X

Reference yield:

2-Chloro-4'-fluoroacetophenone (456-04-2) → SKF 105809 (122454-69-7)

Guidance literature:

Multi-step reaction with 6 steps

1: 75 percent / CHCl₃ / 3 h / Ambient temperature

2: 77 percent / H₂O / 9 h / Heating

3: 75 percent / CH₂Cl₂ / Ambient temperature

4: 56 percent / t-BuOK, t-BuOH, O₂ / 19 h / Heating

5: 73 percent / dimethylformamide / 18 h / 80 °C

6: 60 percent / aq. HCl, NaIO₄ / 18 h / 5 °C

With hydrogenchloride; sodium periodate; potassium tert-butylate; oxygen; tert-butyl alcohol; In dichloromethane; chloroform; water; N,N-dimethyl-formamide;

DOI:10.1016/S0968-0896(96)00212-X

upstream raw materials:

2-(4-methylthiophenyl)-3-(4-pyridyl)-6,7-dihydro-[5H]-pyrrolo-[1,2-a]-imidazole

pyridine

2-Chloro-4'-fluoroacetophenone

2-(4-Fluorophenyl)-6,7-dihydro-(5H)-pyrrolo[1,2-a]imidazole

Downstream raw materials:

2-(4-Acetoxymethylthiophenyl)-3-(4-pyridyl)-6,7-dihydro-[5H]-pyrrolo[1,2-a]-imidazole

2-(4-mercaptophenyl)-3-(pyridin-4-yl)-6,7-dihydro-[5H]pyrrolo[1,2-a]imidazole

Refernces

• 1、 -. "Inhibition of interleukin-1 and tumor necrosis factor production by monocytes and/or macrophages". . . Retrieved 2008/06/13.