4-(4-Bromo-pyrazol-1-yl)-piperidine

Base Information

• Chemical Name: 4-(4-Bromo-pyrazol-1-yl)-piperidine
• CAS No.: 877399-60-5
• Molecular Formula: C8H12BrN3
• Molecular Weight: 230.107
• Hs Code.: 2933990090
• Mol file: 877399-60-5.mol

Synonyms:Piperidine, 4-(4-bromo-1H-pyrazol-1-yl)-;4-(4-Bromopyrazol-1-yl)piperidine;4-(4-Bromo-1H-pyrazol-1-yl)piperidine;

Chemical Property of 4-(4-Bromo-pyrazol-1-yl)-piperidine

Chemical Property:

• Boiling Point: 330.4±32.0 °C(Predicted)
• PKA: 9.76±0.10(Predicted)
• PSA: 29.85000
• Density: 1.67±0.1 g/cm3(Predicted)
• LogP: 1.89890

Purity/Quality:

97% ^*data from raw suppliers

4-(4-Bromo-pyrazol-1-yl)-piperidine 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(4-Bromo-pyrazol-1-yl)-piperidine

There total 1 articles about 4-(4-Bromo-pyrazol-1-yl)-piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

4-(4-bromo-1H-pyrazol-1-yl)piperidine-1-carboxylic acid tert-butyl ester (877399-50-3) → 4-(4-bromo-1H-pyrazol-1-yl)piperidine (877399-60-5)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1021/jm200112k

Reference yield: 65.0%

4-(4-bromo-1H-pyrazol-1-yl)piperidine (877399-60-5) + benzyl bromide (100-39-0) → 1-benzyl-4-(4-bromo-1H-pyrazol-1-yl)piperidine

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield: 63.0%

4-(4-bromo-1H-pyrazol-1-yl)piperidine (877399-60-5) + methyl iodide (74-88-4) → 4-(4-bromo-1H-pyrazol-1-yl)-1-methylpiperidine (877399-61-6)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 20 ℃;

upstream raw materials:

4-(4-bromo-1H-pyrazol-1-yl)piperidine-1-carboxylic acid tert-butyl ester

Downstream raw materials:

4-(4-bromo-1H-pyrazol-1-yl)-1-methylpiperidine

4-(4-bromo-1H-pyrazol-1-yl)piperidine-1-carboxylic acid tert-butyl ester